| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0290 | Name | CDR1-AS | Aliases | CDR1NAT; CDR1as; ciRS-7 | |
| Species | Homo sapiens | Chromosome | X | Start site | N/A | |
| End site | N/A | Chain | N/A | Exon NO. | N/A | |
| Assembly | N/A | Class | N/A | NCBI accession | AK094540 | |
| Ensembl | N/A | Sequence | ||||
| Function (not disease relevant) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
| N/A | mouse brain | N/A | N/A | acts as a miR-7 sponge | 23446346 | ||||
| sequence and computationally analysis, knockdown | N/A | N/A | N/A | CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. | 23446348 | ||||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| miR-7 | RNA-RNA | co-expression | ciRS-7 contains more than 70 selectively conserved miRNA target sites, and it is highly and widely associated with Argonaute (AGO) proteins in a miR-7-dependent manner. Although the circRNA is completely resistant to miRNA-mediated target destabilization, it strongly suppresses miR-7 activity, resulting in increased levels of miR-7 targets. In the mouse brain, we observe overlapping co-expression of ciRS-7 and miR-7, particularly in neocortical and hippocampal neurons, suggesting a high degree of endogenous interaction. | 23446346 | |||||