| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0256 | Name | C1orf74 | Aliases | URLC4 | |
| Species | Homo sapiens | Chromosome | 1 | Start site | 209779208 | |
| End site | 209784559 | Chain | minus | Exon NO. | 2 | |
| Assembly | Ensembl Release 89 | Class | N/A | NCBI accession | N/A | |
| Ensembl | ENSG00000162757 | Sequence | N/A | |||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| gastric cancer | qPCR, Western blot etc. | cell lines (SGC7901, BGC823, SGC7901/DDP, BGC823/DDP etc.) | up-regulated | interaction | The expression of lncRNA AK022798 was significantly higher in all pcDNA3-Notch 1 plasmid treatment groups than in the pcDNA3 plasmid treatment group (P< 0.01).Overexpression of lncRNA AK022798 promotes SGC7901/DDP and BGC823/DDP cells apoptosis.the expression of MRP1 and P-glycoprotein decreased significantly in SGC7901/DDP and BGC823/DDP cells, and their apoptosis as well as the expressions of caspase 3 and caspase 8. | 25763542 | Lnc2Cancer | ||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| Notch 1 | RNA-DNA | regulation | Notch 1 can promote the lncRNA AK022798 expression and result in the formation of SGC7901/DDP and BGC823/DDP cells. | 25763542 | |||||