LncRNA Information
ID EL0239 Name BDNF-AS Aliases ANTI-BDNF; BDNF1; BDNFOS; NCRNA00049; BDNF-AS
Species Homo sapiens Chromosome 11 Start site 27506838
End site 27698174 Chain plus Exon NO. 10
Assembly Ensembl Release 89 Class antisense NCBI accession NR_033312, NR_033315, NR_033313, NR_002832, NR_033314
Ensembl ENSG00000245573 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
obesity N/A N/A N/A mutation Association identified by GWAS (rs4074134, A118887G). 19079260 LncRNADisease
obesity N/A N/A N/A locus This locus maps near key hypothalamic regulators of energy balance, may be associated with obesity. 20935630 LncRNADisease
depression N/A N/A N/A regulation The lncRNA BDNF-AS is related to many neurological disorders, including Huntington's disease (HD), schizophrenia, and depression. 23562612 LncRNADisease
Huntington's disease N/A N/A N/A regulation The lncRNA BDNF-AS is related to many neurological disorders, including Huntington's disease (HD), schizophrenia, and depression. 23562612 LncRNADisease
schizophrenia N/A N/A N/A regulation The lncRNA BDNF-AS is related to many neurological disorders, including Huntington's disease (HD), schizophrenia, and depression. 23562612 LncRNADisease
psychiatric disease N/A N/A N/A regulation Examples of recently discovered chromatin-bound long non-coding RNAs important for neuronal health and function include the brain-derived neurotrophic factor antisense transcript (Bdnf-AS) which regulates expression of the corresponding sense transcript, and LOC389023 which is associated with human-specific histone methylation signatures at the chromosome 2q14.1 neurodevelopmental risk locus by regulating expression of DPP10, an auxillary subunit for voltage-gated K(+) channels. 23831425 LncRNADisease
Huntington's disease N/A N/A N/A regulation Thus, BDNF-AS inhibits BDNF transcription by recruiting EZH2 to the BDNF promoter region and in that way plays an important role in the development of HD. 24624135 LncRNADisease
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
BDNF RNA-RNA binding BDNF and antiBDNF transcripts form dsRNA duplexes in the brain in vivo, suggesting an important role for antiBDNF in regulating BDNF expression in human. 17629449 LncRNADisease
BDNF RNA-RNA binding Human BDNF mRNA and BDNFOS (Opposite Strand) lncRNA form in-vivo RNA–RNA duplexes in brain, suggesting the possibility of post-transcriptional cis-regulation, by BDNFOS, of BDNF. 20951849 LncRNADisease