LncRNA Information
ID EL0237 Name BCYRN1 Aliases BC200; BC200a; LINC00004; NCRNA00004
Species Homo sapiens Chromosome 2 Start site 47335315
End site 47335514 Chain plus Exon NO. 1
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_001568
Ensembl ENSG00000236824 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
esophageal cancer ISH, Northern hybridization etc. esophageal cancer tissue up-regulated expression BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues. 9422992 LncRNADisease Lnc2Cancer
cervical cancer ISH, Northern hybridization etc. cervical cancer tissue up-regulated expression BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues. 9422992 LncRNADisease Lnc2Cancer
ovarian cancer ISH, Northern hybridization etc. ovarian cancer tissue up-regulated expression BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues. 9422992 LncRNADisease Lnc2Cancer
parotid cancer ISH, Northern hybridization etc. parotid cancer tissue up-regulated expression BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues. 9422992 LncRNADisease Lnc2Cancer
breast cancer ISH, Northern hybridization etc. breast cancer tissue up-regulated expression BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues. 9422992 LncRNADisease Lnc2Cancer
tongue cancer ISH, Northern hybridization etc. tongue cancer tissue up-regulated expression BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues. 9422992 LncRNADisease Lnc2Cancer
lung cancer ISH, Northern hybridization etc. lung cancer tissue up-regulated expression BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues. 9422992 LncRNADisease Lnc2Cancer
breast cancer microarray, ISH etc. breast cancer tissue up-regulated expression In ductal carcinomas in situ, furthermore, significant BC200 (BCYRN1) expression was associated with high nuclear grade, suggesting that the presence of BC200 RNA in such tumors may be used as a prognostic indicator of tumor progression. 15240511 LncRNADisease Lnc2Cancer
Alzheimer's disease N/A N/A N/A expression In normal aging, BC200 levels in cortical areas were reduced by >60% between the ages of 49 and 86. In contrast, BC200 RNA was significantly up-regulated in AD brains, in comparison with age-matched normal brains. 17553964 LncRNADisease
Alzheimer's disease N/A N/A N/A expression Increased levels of BC200 were found in brain regions that are preferentially affected in AD. Further, in advanced stages of AD, BC200 was mis-localized and clustered in the perikaryon. These observations suggest that deregulation of these synaptic lncRNAs is involved in the synaptic and neural network dysfunction that is found in both early and later stages of AD. 20380817 LncRNADisease
Alzheimer's disease N/A N/A N/A expression BC200 levels in Brodmann's area 9 (the area of brain affected in AD) were found to be higher in age-matched AD brains compared with normal brains, and the relative levels of BC200 RNA in affected areas increased with the severity of AD. 23562612 LncRNADisease
ovarian cancer ovarian cancer tissue and normal ovarian tissue samples ovarian cancer tissue and normal ovarian tissue samples up-regulated N/A tumor suppressive function in ovarian cancer by affecting cell proliferation 26893717
glioma qPCR etc. cell lines(U251, U87) down-regulated expression MEG3 and ST7OT1 are up-regulated in both cell lines under apoptosis induced using both agents. The induction of GAS5 is only clearly detected during DOX-induced apoptosis, whereas the up-regulation of neat1 and MIR155HG is only found during RES-induced apoptosis in both cell lines. However, TUG1, BC200 and MIR155HG are down regulated when necrosis is induced using a high dose of DOX in both cell lines. 25645334 Lnc2Cancer
non-small-cell lung cancer RT-PCR, knowdown, over-expression, ChIP non-small-cell lung cancer (NSCLC) up-regulated expression These findings uncover a regulatory mechanism in NSCLC cells involving the metastasis-promoting lncRNA BCYRN1 that improves expressions of the key metastasis-supporting proteins MMP9 and MMP13. 25866480
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
BC200 truncations and RNase footprinting assays, pull-down assays N/A N/A interaction Tests performed to assess whether BC200 interferes with RHAU helicase activity have demonstrated the ability of BC200 to act as an acceptor of unwound quadruplexes via a cytosine-rich region near the 3'-end of the RNA. RHAU may direct BC200 to bind and exert regulatory functions at quadruplex-containing RNA or DNA sequences. 26740632
N/A N/A N/A interaction Competition experiments using variants of bc1 and bc200 rnas demonstrated that the central adenosine-rich region of both rnas mediates binding to pabp. 12162957
N/A rabbit reticulocyte lysate system, HeLa cells N/A interaction In vivo, all bc1 rna appears to be complexed with pabp. nevertheless, in the micro-environment of dendritic spines of neuronal cells, bc1 rnps or bc200 rnps might mediate regulatory functions by differential interactions with locally limited pabp and/or directly or indirectly, with other translation initiation factors. 16154588
N/A N/A N/A expression In normal aging, BC200 levels in cortical areas were reduced by >60% between the ages of 49 and 86. In contrast, BC200 RNA was significantly up-regulated in AD brains, in comparison with age-matched normal brains. 17553964 LncRNADisease
N/A N/A N/A interaction A protein that binds bc200 rna in vivo is immunoreactive with antibodies against srp9. 9605471
transgenic transgenic mice N/A expression when all upstream regions of the G22 gene were removed, expression was completely abolished, despite the presence of intact internal RNA polymerase III promoter elements 17175535
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
PABP RNA-Protein binding Competition experiments using variants of bc1 and bc200 rnas demonstrated that the central adenosine-rich region of both rnas mediates binding to pabp. 12162957
PABP RNA-Protein binding In vivo, all bc1 rna appears to be complexed with pabp. nevertheless, in the micro-environment of dendritic spines of neuronal cells, bc1 rnps or bc200 rnps might mediate regulatory functions by differential interactions with locally limited pabp and/or directly or indirectly, with other translation initiation factors. 16154588
SRP9/14 heterodimer RNA-Protein binding Inhibits translation. Binds PABP, SRP9/14 heterodimer and eIF4A. 17175535 LncRNADisease
G22 RNA-Protein co-expression when all upstream regions of the G22 gene were removed, expression was completely abolished, despite the presence of intact internal RNA polymerase III promoter elements 17175535
eIF4A RNA-Protein binding Inhibits translation. Binds PABP, SRP9/14 heterodimer and eIF4A. 18316401 LncRNADisease
c-MYC DNA-Protein binding ChIP assay confirmed the binding of c-MYC to the promoter region of BCYRN1 gene. 25866480
the quadruplex-containing telomerase RNA RNA-RNA regulation An interaction between BC200 and the quadruplex-containing telomerase RNA was confirmed by pull-down assays of the endogenous RNAs. 26740632
RHAU RNA-Protein binding RHAU binds to an adenosine-rich region near the 3'-end of the RNA. RHAU truncations support binding that is dependent upon a region within the C terminus and is specific to RHAU isoform 1. 26740632
PABP RNA-Protein binding Inhibits translation. Binds PABP, SRP9/14 heterodimer and eIF4A. 7684772 LncRNADisease
SRP9 RNA-Protein binding A protein that binds bc200 rna in vivo is immunoreactive with antibodies against srp9. 9605471