LncRNA Information
ID EL0234 Name Bc1 Aliases Gm24367
Species Mus musculus Chromosome 7 Start site 144914470
End site 144914623 Chain plus Exon NO. 1
Assembly GRCm38.p4 Class N/A NCBI accession NR_038088
Ensembl N/A Sequence


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
Biochemical experiments nerve cells N/A interaction Bc1-mediated repression targets translation at the level of initiation. specifically, bc1 rna inhibited formation of the 48s preinitiation complex 12451124
eliminate the BC1 RNA gene N/A N/A expression The lack of bc1 rna appears to reduce exploratory activity. 12944471
N/A N/A N/A interaction Competition experiments using variants of bc1 and bc200 rnas demonstrated that the central adenosine-rich region of both rnas mediates binding to pabp. 12162957
N/A controls and knockout mice N/A expression The neuron-specific non-messenger bc1 rna contributes to the aptive modulation of behaviour. 15302134
N/A rabbit reticulocyte lysate system, HeLa cells N/A interaction In vivo, all bc1 rna appears to be complexed with pabp. nevertheless, in the micro-environment of dendritic spines of neuronal cells, bc1 rnps or bc200 rnps might mediate regulatory functions by differential interactions with locally limited pabp and/or directly or indirectly, with other translation initiation factors. 16154588
Western-blot Oocytes N/A interaction Interactions of this domain with eukaryotic initiation factor 4A and poly(A) binding protein mediate repression;BC1 RNA modulates translation-dependent processes in neurons and germs cells by directly interacting with translation initiation factors. 16330711
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
PABP RNA-Protein binding Competition experiments using variants of bc1 and bc200 rnas demonstrated that the central adenosine-rich region of both rnas mediates binding to pabp. 12162957
eIF4A RNA-DNA regulation A specific interaction of bc1 rna with eif4a, an rna unwinding factor, and with poly(a)-binding protein. 12451124
PABP RNA-Protein binding In vivo, all bc1 rna appears to be complexed with pabp. nevertheless, in the micro-environment of dendritic spines of neuronal cells, bc1 rnps or bc200 rnps might mediate regulatory functions by differential interactions with locally limited pabp and/or directly or indirectly, with other translation initiation factors. 16154588
eukaryotic initiation factor 4A and poly(A) binding protein, the fragile X mental retardation protein RNA-Protein binding Interactions of this domain with eukaryotic initiation factor 4A and poly(A) binding protein mediate repression;BC1 RNA modulates translation-dependent processes in neurons and germs cells by directly interacting with translation initiation factors. 16330711