LncRNA Information
ID EL0227 Name BANCR Aliases LINC00586
Species Homo sapiens Chromosome 9 Start site 69296682
End site 69306977 Chain minus Exon NO. 4
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_047671
Ensembl ENSG00000278910 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
colorectal cancer chromatin immunoprecipitation; luciferase assays; RT-PCR fentanyl-treated colorectal cancer (CRC) cells up-regulated expression Fentanyl induced BANCR upregulation and Ets-1 downregulation in CRC cells. Further studies showed that Ets-1 negatively regulated BANCR expression via the deacetylation of histones H3 within BANCR promoter. Ets-1 overexpression inhibited fentanyl-induced effects that could be reversed by BANCR co-overexpression 26296467
melanoma microarray, RNA-seq, qPCR etc. cell lines (293T, sk-mel-5, Colo-829 etc.) up-regulated N/A BRAF-regulated lncRNA 1 (BANCR) was identified as a recurrently overexpressed, previously unannotated 693-bp transcript on chromosome 9 with a potential functional role in melanoma cell migration. 22581800 LncRNADisease Lnc2Cancer
melanoma N/A N/A N/A regulation This screen revealed a 693 bp novel lncRNA transcript, named BRAF-activated non-coding RNA (BANCR).Depletion of BANCR in melanoma cells resulted in profound migration defects, indicating a significant role of BANCR in regulation of melanoma cell motility. 24115003 LncRNADisease
gastric cancer qPCR etc. gastric cancer tissue up-regulated interaction In our results, the expression of BANCR was increased in gastric cancer tissues compared with paired adjacent normal tissues. Moreover, high expression of BANCR was positively associated with clinical stage, tumor depth, lymph node metastasis and distant metastasis in gastric cancer patients. BANCR overexpression was an independent unfavorable prognostic biomarker for gastric cancer patients. 26054683 Lnc2Cancer
retinoblastoma qPCR, knockdown etc. retinoblastoma tissue, cell lines (Weri-Rb1, Y79) up-regulated expression In our results, lncRNA BANCR is overexpressed in retinoblastoma tissues and cell lines and is associated with tumor size, choroidal invasion, and optic nerve invasion. lncRNA BANCR plays a significant role in retinoblastoma aggressiveness and prognosis and may act as a promising target for therapeutic strategy and prognostic prediction. 25894373 Lnc2Cancer
papillary thyroid carcinoma qPCR, knockdown, RIP, FCA etc. PTC tissue, cell line (IHH-4) up-regulated interaction The expression of BANCR was significantly up-regulated while PTCSC3 and NAMA were significantly down-regulated in papillary thyroid carcinoma (PTC) compared to that in normal tissue. BANCR-knockdown in a PTC-derived cell line (IHH-4) resulted in significant suppression of thyroid stimulating hormone receptor (TSHR). BANCR-knockdown also led to inhibition of cell growth and cell cycle arrest at G0/G1 phase through down-regulation of cyclin D1. In addition, BANCR was enriched by polycomb enhancer of zeste homolog 2 (EZH2), and silencing BANCR led to decreased chromatin recruitment of EZH2, which resulted significantly reduced expression of TSHR. 26323637 Lnc2Cancer
colorectal cancer qPCR, Western blot etc. colorectal cancer tissue up-regulated N/A The quantitative polymerase chain reaction results showed that BANCR was frequently overexpressed in cancer tissues and this overexpression was found to significantly correlate with lymph node metastasis and tumour stage. The ectopic expression of BANCR contributed to the migration of human CRC Caco-2 cells, whereas knockdown of BANCR inhibited the migration of the HCT116 cells in vitro. Further investigation into the underlying mechanisms responsible for the migratory effects revealed that BANCR induced the epithelial-mesenchymal transition (EMT) through an MEK/extracellular signal-regulated kinase-dependent mechanism as treatment with the MEK inhibitor, U0126 decreased migration and reversed the EMT in the BANCR-overexpressed HCT116 cells. 25013510 Lnc2Cancer
lung cancer qPCR, Western blot etc. lung cancer tissue, cell lines (NCI-H1688, NCI-H446) down-regulated expression The results showed that BANCR levels were downregulated in LC cells. When BANCR expression was improved by tranfetcion with pcDNA-BANCR vetcor, tumor growth was suppressed.Vise versa, when BANCR was knockdown by si-BANCR, cell proliferation and migration of LC were remarkably promoted. We further found that MAPK pathways were involved in the BANCR-mediated cell proliferation and migration of LC. 25661343 Lnc2Cancer
papillary thyroid carcinoma qPCR, Western blot, FCA etc. PTC tissue, cells line (IHH-4) up-regulated expression The results revealed that BANCR levels were significantly higher in the PTC tissues and PTC IHH-4 cells compared with the normal controls. Knockdown of BANCR in the IHH-4 cells inhibited proliferation and increased apoptosis of the cells in vitro. Further investigation of the underlying mechanisms revealed that BANCR markedly activated autophagy. Overexpression of BANCR inhibited apoptosis in the IHH-4 cells, whereas inhibition of autophagy stimulated apoptosis in the BANCR-overexpressed cells. BANCR overexpression also increased cell proliferation and the inhibition of autophagy abrogated BANCR overexpression-induced cell proliferation. 25289082 Lnc2Cancer
malignant melanoma qPCR, Western blot, in vitro knockdown etc. malignant melanoma tissue, cell lines (A-375, 1205Lu, UACC903, CHL-1 and sk-mel-5 etc.) up-regulated N/A BANCR was abnormally overexpressed in human malignant melanoma cell lines and tissues, and increased with tumor stages.The linkage between BANCR and MAPK pathway may provide a novel interpretation for the mechanism of proliferation regulation in malignant melanoma 24967732 Lnc2Cancer
non-small cell lung cancer qPCR, Western blot, knockdown etc. NSCLC tissue, cell lines (A549, SPC-A1, NCI-H1975, SK-MES-1 etc.) down-regulated expression Downregulation of BRAF activated non-coding RNA is associated with poor prognosis for non-small cell lung cancer and promotes metastasis by affecting epithelial-mesenchymal transition. 24655544 LncRNADisease Lnc2Cancer
colorectal cancer qPCR, Western blot, knockdown etc. colorectal cancer tissue, cell lines (SW480, HCT116, RQO, HT-29 etc.) down-regulated interaction In this study, we show that BANCR expression was significantly down-regulated in colorectal cancer tissues compared with normal tissues, and overexpression of BANCR suppressed colorectal cancer cell growth in vitro and in vivo.Down_regulation of BANCR contributes to theproliferation of colorectal cancer cells,at least in part,through the regulation of p21 protein. 25928067 Lnc2Cancer
gastric adenocarcinoma qPCR, Western blot, knockdown, MTT assay etc. gastric adenocarcinoma tissue, cell lines (BGC823, SGC7901) up-regulated interaction BANCR expression was significantly up-regulated in gastric tumor tissues and gastric cell lines. Down-regulation of BANCR inhibited gastric cancer cell growth and promoted cell apoptosis, and it also contributed to a significant decrease of NF-B1 (P50/105) expression and 3'UTR of NF-B1 activity. Overexpression of NF-B1 reversed the effect of BANCR on cancer cell growth and apoptosis. MiroRNA-9 (miR-9) targeted NF-B1, and miR-9 inhibitor also reversed the effects of BANCR on gastric cancer cell growth and apoptosis. 26248136 Lnc2Cancer
hepatocellular carcinoma quantitative real-time PCR (qRT-PCR), overexpression, downregulation, flow cytometry, and transwell invasion and migration assays human hepatocellular carcinoma tissues up-regulated expression BANCR may contribute to HCC initiation and progression and would be used as not only a novel prognostic marker but also a potential therapeutic target for this disease. 26758762
osteosarcoma real-time PCR osteosarcoma cell lines and clinical specimens down-regulated N/A BANCR expression was significantly associated with large tumor size; MG-63 cell proliferation 27051014
Eosinophilic esophagitis RNA sequencing healthy controls and patients with active EoE up-regulated expression Repression of BANCR significantly altered the expression of IL-13-induced proinflammatory genes. 24920534
osteosarcoma RT-PCR, Western blotting and CCK-8 assay MG-63 cells up-regulated expression After the construct pcDNA3.1-BANCR (BRAF-regulated lncRNA 1) was transfected into MG-63 cells, RT-PCR, Western blotting and CCK-8 assay showed that BANCR was positively correlated with baicalein. 25893737
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
p21 RNA-DNA regulation our findings suggest that down-regulation of BANCR contributes to the proliferation of colorectal cancer cells, at least in part, through the regulation of p21 protein. 25928067
BRAF RNA-DNA regulation little is known about the clinical significance of BRAF-activated non-coding RNA (BANCR) in gastric cancer. 26054683
NF-κB1 RNA-TF regulation Down-regulation of BANCR contributed to a significant decrease of NF-κB1 (P50/105) expression and 3'UTR of NF-κB1 activity. Overexpression of NF-κB1 reversed the effect of BANCR on cancer cell growth and apoptosis. 26248136
MiroRNA-9 (miR-9) RNA-RNA regulation MiroRNA-9 (miR-9) targeted NF-κB1, and miR-9 inhibitor also reversed the effects of BANCR on gastric cancer cell growth and apoptosis. 26248136
Ets-1 DNA-Protein regulation Ets-1 negatively regulated BANCR expression via the deacetylation of histones H3 within BANCR promoter. 26296467
zeste homolog 2 (EZH2) RNA-Protein regulation BANCR was enriched by polycomb enhancer of zeste homolog 2 (EZH2), and silencing BANCR led to decreased chromatin recruitment of EZH2, which resulted significantly reduced expression of TSHR. 26323637
cyclin D1 RNA-Protein regulation BANCR-knockdown also led to inhibition of cell growth and cell cycle arrest at G0/G1 phase through down-regulation of cyclin D1. 26323637
thyroid stimulating hormone receptor (TSHR) RNA-Protein regulation BANCR-knockdown in a PTC-derived cell line (IHH-4) resulted in significant suppression of thyroid stimulating hormone receptor (TSHR). 26323637