LncRNA Information
ID EL0222 Name B2 SINE RNA Aliases N/A
Species Mus musculus Chromosome N/A Start site N/A
End site N/A Chain N/A Exon NO. N/A
Assembly N/A Class N/A NCBI accession N/A
Ensembl N/A Sequence N/A


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
infection of chicken embryo lethal orphan adenovirus N/A N/A N/A Interaction CELO protein Gam1 was able to mediate transcriptional activation of these B2 SINE-containing RNAs. Upregulation of B2-SINE-containing RNAs could be a novel contribution of Gam1 to CELO host cell infection. 12729754 LncRNADisease
heat shock N/A heat shocked cells N/A interaction B2 rna potently inhibits transcription by binding to core pol ii with high affinity and specificity. 15300239
heat shock N/A N/A N/A interaction A small noncoding rna polymerase iii transcript, b2 rna, associates with rna polymerase ii and represses transcription of specific mrna genes. 15300240
infection of mouse minute virus N/A N/A N/A expression Increased levels of B1 and B2 SINE transcripts in mouse fibroblast cells due to minute virus of mice infection. 15351211 LncRNADisease
pain N/A N/A N/A expression Comt1 is differentially expressed among the strains, and this differential expression is cis-regulated. A B2 short interspersed nuclear element (SINE) was inserted in the 3'-untranslated region (3'-UTR) of Comt1 in 14 strains generating a common haplotype that correlates with gene expression. A haplotype, defined by a 3'-UTR B2 SINE element, regulates Comt1 expression and some mouse behaviors. 20659173 LncRNADisease
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
electrophoretic mobility shift assays plasmids N/A interaction In vitro B2 RNA assembles into preinitiation complexes on promoter DNA via its interaction with the polymerase, thus rendering the complexes inactive. 17307818
N/A N/A N/A epigenetics miR-468-mediated suppression of LSH leads to aberrant methylation of LINE1 and SINE B2. 19959559 LncRNADisease
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
RNA polymerase II DNA-DNA regulation Transposable B2 SINE elements can provide mobile RNA polymerase II promoters. 11326281 LncRNADisease
CELO DNA-TF regulation CELO protein Gam1 was able to mediate transcriptional activation of these B2 SINE-containing RNAs. 12729754 LncRNADisease
Pol II RNA-Protein binding B2 rna potently inhibits transcription by binding to core pol ii with high affinity and specificity. 15300239
Pol II RNA-Protein binding A small noncoding rna polymerase iii transcript, b2 rna, associates with rna polymerase ii and represses transcription of specific mrna genes. 15300240
RNA polymerase II RNA-Protein binding A 33-nt piece of B2 RNA binds RNA polymerase II, associates with preinitiation complexes, but cannot repress transcription. 17307818 LncRNADisease
RNA polymerase II RNA-Protein binding In vitro B2 RNA assembles into preinitiation complexes on promoter DNA via its interaction with the polymerase, thus rendering the complexes inactive. 17307818
ALAS1 DNA-DNA regulation A B2 SINE can contribute to the regulation of ALAS1 and SINEs in 5'-UTR regions contribute to inter-individual differences in gene expression. 18929534 LncRNADisease
actin RNA-RNA co-expression Upon stress conditions such as heat shock, B2 expression is dramatically enhanced leading to repression of transcription for genes such as actin and hexokinase II. 19239885 LncRNADisease
hexokinase II RNA-RNA co-expression Upon stress conditions such as heat shock, B2 expression is dramatically enhanced leading to repression of transcription for genes such as actin and hexokinase II. 19239885 LncRNADisease
Comt1 DNA-DNA regulation A B2 SINE insertion in the Comt1 gene (Comt1(B2i)) results in an overexpressing, behavior modifying allele present in classical inbred mouse strains.Comt1(B2i) (a B2 SINE insertion) results in a relatively modest difference in Comt1 expression and enzyme activity (comparable to the human Val-Met polymorphism) which has a demonstrable behavioral phenotype across a variety of outbred genetic backgrounds. 20618449 LncRNADisease
Comt1 DNA-DNA regulation Comt1 is differentially expressed among the strains, and this differential expression is cis-regulated. A B2 short interspersed nuclear element (SINE) was inserted in the 3'-untranslated region (3'-UTR) of Comt1 in 14 strains generating a common haplotype that correlates with gene expression. A haplotype, defined by a 3'-UTR B2 SINE element, regulates Comt1 expression and some mouse behaviors. 20659173 LncRNADisease