LncRNA Information
ID EL0076 Name AOC4P Aliases AOC4; UPAT
Species Homo sapiens Chromosome 17 Start site 42865922
End site 42874369 Chain plus Exon NO. 1
Assembly Ensembl Release 89 Class processed transcript NCBI accession NR_002773
Ensembl ENSG00000260105 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
colorectal cancer N/A colorectal cancer cells N/A interaction UPAT interacts with and stabilizes the epigenetic factor UHRF1 by interfering with its β-transducin repeat-containing protein (TrCP)-mediated ubiquitination. UHRF1 up-regulates Stearoyl-CoA desaturase 1 and Sprouty 4, which are required for the survival of colon tumor cells. 26768845
hepatocelluar carcinoma qPCR, Western blot, RNA pulldown assay, knockdown, HCC tissue, cell lines (J7 and SK-Hep1) down-regulated interaction we identified a differentially expressed novel tumor suppressive lncRNA termed amine oxidase, copper containing 4, pseudogene (AOC4P). The level of AOC4P expression was significantly downregulated in 68% of HCC samples and negatively correlated with advanced clinical stage, capsule invasion and vessel invasion. Low AOC4P expression correlated with poor prognostic outcomes, serving as an independent prognostic factor for HCC. In vitro functional assays indicated that AOC4P overexpression significantly reduced cell proliferation, migration and invasion by inhibiting the epithelial-mesenchymal transition (EMT) 26160837 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
vimentin RNA-Protein binding AOC4P binds to vimentin and promotes its degradation. 26160837
UHRF1 RNA-Protein regulation UPAT interacts with and stabilizes the epigenetic factor UHRF1 by interfering with its β-transducin repeat-containing protein (TrCP)-mediated ubiquitination. 26768845