| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0985 | Name | NORAD | Aliases | LINC00657 | |
| Species | Homo sapiens | Chromosome | 20 | Start site | 36045622 | |
| End site | 36050960 | Chain | minus | Exon NO. | 1 | |
| Assembly | Ensembl Release 89 | Class | lincRNA | NCBI accession | NR_027451 | |
| Ensembl | ENSG00000260032 | Sequence | ||||
| Function (not disease relevant) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
| N/A | previously karyotypically stable cell lines | N/A | interaction | Inactivation of NORAD triggers dramatic aneuploidy in previously karyotypically stable cell lines. | 26724866 | ||||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| PUMILIO | RNA-Protein | regulation | NORAD maintains genomic stability by sequestering PUMILIO proteins, which repress the stability and translation of mRNAs to which they bind. In the absence of NORAD, PUMILIO proteins drive chromosomal instability by hyperactively repressing mitotic, DNA repair, and DNA replication factors. | 26724866 | |||||