LncRNA Information
ID EL0869 Name MIAT Aliases C22orf35; GOMAFU; LINC00066; NCRNA00066; RNCR2; lncRNA-MIAT
Species Homo sapiens Chromosome 22 Start site 26646428
End site 26676475 Chain plus Exon NO. 5
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_003491, NR_033319, NR_033320, NR_033321
Ensembl ENSG00000225783 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
myocardial infarction N/A N/A N/A mutation In vitro functional analyses revealed that the minor variant of one SNP in exon 5 increased transcriptional level of MIAT. Moreover, unidentified nuclear protein(s) bound more intensely to risk allele than non-risk allele. These results indicate that the altered expression of MIAT by the SNP may play some role in the pathogenesis of MI. 17066261 LncRNADisease
myocardial infarction N/A N/A N/A mutation SNPs associated with myocardial infarction localized to a haplotype block that encompassed the last 3 exons of MIAT. 20951849 LncRNADisease
drug abuse N/A N/A N/A expression MIAT turned out to be one of the top twenty-five, of nearly 39,000, transcripts differentially expressed in the nucleus accumbens,a midbrain region pivotal in drug abuse, in a case-control study of human heroin and cocaine abusers. 20951849 LncRNADisease
heroin abuse N/A N/A N/A expression The lncRNA MIAT is upregulated in heroin abusers. 21128942 LncRNADisease
myocardial infarction N/A N/A N/A mutation MIAT lincRNA Variants Confer Susceptibility to Myocardial Infarction 23104877 LncRNADisease
schizophrenia N/A N/A N/A expression Finally, we show that Gomafu is downregulated in post-mortem cortical gray matter from the superior temporal gyrus in SZ. 23628989 LncRNADisease
myocardial infarction N/A N/A N/A regulation A myocardial infarction-associated transcript (MIAT), also known as RNCR2 or Gomafu, is a long intergenic non-coding RNA that presents many genetic variants implicated in different processes. A large scale case-control association study regarding cardiovascular disease demonstrates that a MIAT variant (rs2301523) confers susceptibility to myocardial infarction. 24113581 LncRNADisease
cancer N/A N/A N/A regulation Another lncRNA serving as oncogene is retinal noncoding RNA 2 (RNCR2). 24757675 LncRNADisease
acute myocardial infarction N/A N/A N/A N/A Patients with ST-segment-elevation MI had lower levels of myocardial infarction-associated transcript (P<0.001)when compared with patients with non-ST-segment-elevation 25035150 LncRNADisease
diabetes mellitus-induced microvascular dysfunction qPCR, RIP diabetic retinas and endothelial cells cultured in high glucose medium up-regulated expression This study highlights the involvement of lncRNA-MIAT in pathological angiogenesis and facilitates the development of lncRNA-directed diagnostics and therapeutics against neovascular diseases. 25587098
paranoid schizophrenia two-stage association analysis sample from patients with paranoid schizophrenia N/A expression Long non-coding RNAs (LncRNAs) are involved in multiple processes critical to normal cellular function and dysfunction of lncRNA MIAT may contribute to the pathophysiology of schizophrenia. The present studies showed that lncRNA MIAT was a novel susceptibility gene for paranoid schizophrenia in the Chinese Han population. 26004688
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
knockdown,cross-link RNA precipitation analysis neuroblastoma cell line Neuro2A down-regulated interaction Gomafu indirectly modulates the function of the splicing factors SF1 and Celf3 by sequestering these proteins into separate nuclear bodies. 25145264
RT-PCR, knockdown cataractous lens epithelial cells, plasma fraction of whole blood and aqueous humor of cataract patients up-regulated interaction MIAT knockdown could affect the proliferation, apoptosis and migration of Human lens epithelial cells (HLECs) upon oxidative stress. MIAT knockdown could repress tumour necrosis factor-α-induced abnormal proliferation and migration of HLECs, suggesting a potential role of MIAT in PCO-related pathological process. MIAT acted as a ceRNA, and formed a feedback loop with Akt and miR-150-5p to regulate HLEC function. 26818536
TaqMan gene expression assays, QPCR human TK6 (p53 positive) and WTK1 (p53 negative) cells up-regulated expression The MIAT and PIWIL1 were upregulated in WTK1 cells. 23698766
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
IRES-GFP DNA-DNA regulation fusion of RNCR2 to an IRES-GFP sequence results in mislocalization of this nuclear RNA to the cytoplasm. 20459797 LncRNADisease
SF1 RNA-Protein binding Celf3 formed novel nuclear bodies (named CS bodies) that colocalized with SF1, another Gomafu-binding protein. 25145264
Celf3 RNA-Protein binding The RNA-binding protein Celf3 as a novel Gomafu-associating protein. Knockdown of Celf3 led to the down-regulation of Gomafu, and cross-link RNA precipitation analysis confirmed specific binding between Celf3 and Gomafu. 25145264
Akt RNA-Protein regulation MIAT acted as a ceRNA, and formed a feedback loop with Akt and miR-150-5p to regulate HLEC function. 26818536
miR-150-5p RNA-RNA regulation MIAT acted as a ceRNA, and formed a feedback loop with Akt and miR-150-5p to regulate HLEC function. 26818536