| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0850 | Name | LUNAR1 | Aliases | Leukemia-Associated Non-Coding IGF1R Activator RNA 1; RP11-6O2.2 | |
| Species | Homo sapiens | Chromosome | 15 | Start site | 99028538 | |
| End site | 99031053 | Chain | plus | Exon NO. | 4 | |
| Assembly | Ensembl Release 89 | Class | lincRNA | NCBI accession | NR_126487 | |
| Ensembl | ENSG00000278090 | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| diffuse large B-cell lymphoma | Quantitative real-time PCR, knockdown | Diffuse large B-cell lymphoma (DLBCL) tissues and cell lines | N/A | interaction | The higher expression of LUNAR1 was significantly correlated with stage, rituximab and IPI. Univariate and multivariate analyses showed that LUNAR1 expression served as an independent predictor for overall survival and progression-free survival. LUNAR1 may serve as a candidate prognostic biomarker through growth regulation in DLBCL. | 26796267 | |||
| T cell acute lymphoblastic leukemia | RNA-seq, qPCR etc. | blood | up-regulated | interaction | We have shown that one specific Notch-regulated lncRNA, LUNAR1, is required for efficient T-ALL growth in vitro and in vivo due to its ability to enhance IGF1R mRNA expression and sustain IGF1 signaling. | 25083870 | Lnc2Cancer | ||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| IGF1R | RNA-RNA | regulation | one specific Notch-regulated lncRNA, LUNAR1, is required for efficient T-ALL growth in vitro and in vivo due to its ability to enhance IGF1R mRNA expression and sustain IGF1 signaling. | 25083870 | |||||
| E2F1, cyclin D1 and p21 | RNA-Protein | regulation | LUNAR1 knockdown significantly repressed cell proliferation of DLBCL by regulating E2F1, cyclin D1 and p21. | 26796267 | |||||