LncRNA Information
ID EL0849 Name LUCAT1 Aliases SCAL1
Species Homo sapiens Chromosome 5 Start site 91303029
End site 91314402 Chain minus Exon NO. 6
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_103548, NR_103549
Ensembl ENSG00000248323 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
lung cancer qPCR, Western bolt, RIP etc. cell lines (A549, CL1-0, CL1-5, H1975, HCC-827, NCI-H292 etc.) up-regulated N/A We found that XLOC_004924 was elevated in the airway epithelia of cigarette smokers versus nonsmokers in both of these datasets. In the first dataset, five nonsmokers were compared with six smokers. In the second study, the smokers' epithelia demonstrated a 3.9-fold increase in XLOC_004924, compared with nonsmokers. Functionally,siRNA knockdown of SCAL1 in HBE1 cells shows significant potentiation of cytotoxicity induced by CSE in vitro. Altogether, these results identify a novel and intriguing new non-coding RNA that may act downstream of NRF2 to regulate gene expression and mediate oxidative stress protection in airway epithelial cells. 23672216 Lnc2Cancer