LncRNA Information
ID EL0848 Name LUADT1 Aliases N/A
Species Homo sapiens Chromosome 6 Start site 147158925
End site 147180992 Chain plus Exon NO. 3
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_132442
Ensembl ENSG00000196634 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
lung adenocarcinoma microarray, qPCR, Western blot, knockdown, Luciferase reporter assay etc. lung cancer tissues and adjacent non-tumor tissues, cell lines ( A549, H1975, H358, H1650 and H1299A549, H1975, H358, H1650 and H1299 ) up-regulated interaction LUADT1 may regulate cell cycle progression by epigenetically inhibiting the expression of p27. RNA immunoprecipitation and chromatin immunoprecipitation assays confirmed that LUADT1 binds to SUZ12, a core component of polycomb repressive complex 2, and mediates the trimethylation of H3K27 at the promoter region of p27. The negative correlation between LUADT1 and p27 expression was confirmed in LUAD tissue samples. LUADT1 is an oncogenic lncRNA that regulates LUAD progression, suggesting that dysregulated lncRNAs may serve as key regulatory factors in LUAD progression 26291312 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
p27 RNA-DNA regulation LUADT1 binds to SUZ12, a core component of polycomb repressive complex 2, and mediates the trimethylation of H3K27 at the promoter region of p27. 26291312
SUZ12 RNA-Protein binding LUADT1 binds to SUZ12, a core component of polycomb repressive complex 2, and mediates the trimethylation of H3K27 at the promoter region of p27. 26291312