LncRNA Information
ID EL0822 Name LOC105246506 Aliases N/A
Species Mus musculus Chromosome 18 Start site 80186239
End site 80193569 Chain plus Exon NO. 5
Assembly GRCm38.p4 Class N/A NCBI accession NR_131039
Ensembl N/A Sequence


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
combined full-length mESC transcriptome genomic mapping data with chromatin immunoprecipitation genomic location maps of the key mESC transcription factors mouse embryonic stem cells (mESCs) N/A Interaction potential roles in pluripotency 20026622
in vitro knowdown, qRT-PCR mESC (mouse embryonic stem cells), MSC (mice mesenchymal stem cells) up-regulated interaction AK141205 positively promoted CXCL13 expression via acetylation of H4 histone in the promoter region;In summary, we report a completely novel role of AK141205/CXCL13 as a regulator of OGP-induced osteogenic differentiation of SMCs. Our finding provides a potential therapeutic targeting of AK141205 for enhancing disease-treatment effect of SMCs. (PMID:26321662). When overexpressed, AK141205 led to an increase in Oct4 mRNA and to a corresponding up-regulation of endodermal markers, in addition to initiating meso- and ectodermal differentiation. (PMID:20026622). 26321662; 20026622
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
Nanog DNA-TF regulation AK141205 is repressed by the transcription factor Nanog. 20026622 LncRNADisease
Oct4 and Nanog RNA-DNA binding AK028326 (Oct4-activated) and AK141205 (Nanog-repressed), are direct targets of Oct4 and Nanog. 20026622
CXCL13; Nanog RNA-Protein regulation Analysis of CXCL13 expression in SMCs(pcDNA-AK141205) revealed that AK141205 positively promoted CXCL13 expression via acetylation of H4 histone in the promoter region (co-expression); Nanog may directly repress transcription of lncRNA AK141205 (regulation). 26321662; 20026622