| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0695 | Name | LINC01426 | Aliases | lincRNA-uc002yug.2 | |
| Species | Homo sapiens | Chromosome | 21 | Start site | 34745757 | |
| End site | 34784886 | Chain | plus | Exon NO. | 4 | |
| Assembly | Ensembl Release 89 | Class | antisense | NCBI accession | NR_038885, NR_038886 | |
| Ensembl | ENSG00000234380 | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| esophageal squamous cell carcinoma | qPCR, Luciferase reporter assay, Western blot etc. | ESCC tissue | up-regulated | expression | We found that lincRNA-uc002yug.2 was commonly overexpressed in ESCC. Moreover, lincRNA-uc002yug.2 promoted a combination of RUNX1 and alternative splicing (AS) factors in the nucleus to produce more RUNX1a, the short isoform and inhibitor of RUNX1, and reduce CEBPa (CCAAT/enhancer-binding protein-a) gene expression, thereby promoting ESCC progression. The expression levels of lincRNA-uc002yug.2 in ESCC might be a prognostic factor for survival. | 25486427 | Lnc2Cancer | ||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| RUNX1 and alternative splicing (AS) factors | RNA-Protein | regulation | lincRNA-uc002yug.2 promoted a combination of RUNX1 and alternative splicing (AS) factors in the nucleus to produce more RUNX1a, the short isoform and inhibitor of RUNX1, and reduce CEBPα (CCAAT/enhancer-binding protein-α) gene expression | 25486427 | |||||