| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0676 | Name | LINC00974 | Aliases | N/A | |
| Species | Homo sapiens | Chromosome | 17 | Start site | 41549606 | |
| End site | 41554495 | Chain | minus | Exon NO. | 3 | |
| Assembly | Ensembl Release 89 | Class | lincRNA | NCBI accession | NR_038442 | |
| Ensembl | ENSG00000226629 | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| hepatocelluar carcinoma | qPCR, in vitro knockdown, RIP etc. | HCC tissue, blood(plasma) | up-regulated | interaction | Knockdown of Linc00974 resulted in an inhibition of cell proliferation and invasion with an activation of apoptosis and cell cycle arrest in vitro.The combination of Linc00974 and KRT19 may be novel indices for clinical diagnosis of tumor growth and metastasis in HCC, while Linc00974 may become a potential therapeutic target for the prevention of HCC progression. We also discovered Linc00974F-1 stably expressed in the plasma. | 25476897 | Lnc2Cancer | ||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| KRT19 | RNA-RNA | co-expression | Linc00974 was increased owing to an abnormal hypomethylation promoter, which induced the upregulation of KRT19 via ceRNA interaction, resulting in the activation of the Notch and TGF-β pathways as detected by cDNA microarray. | 25476897 | |||||