LncRNA Information
ID EL0651 Name LINC00261 Aliases ALIEN; C20orf56; DEANR1; HCCDR1; NCRNA00261; onco-lncRNA-17
Species Homo sapiens Chromosome 20 Start site 22547671
End site 22578642 Chain minus Exon NO. 4
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_001558
Ensembl ENSG00000259974 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
non-small cell lung cancer microarray, qPCR etc. NSCLC tissue down-regulated expression Furthermore, the levels of LINC00261 and TP73-AS1 were significantly differently expressed in subgroups of NSCLC samples.These lncRNAs could be further exploited for the development of useful biomarkers in diagnosis, prognosis and treatment of NSCLC. 25590602 Lnc2Cancer
gastric cancer microarray, qPCR etc. gastric cancer tissue, cell lines (HCG-27, SGC-7901) down-regulated expression Linc00261, DKFZP434K028 and RPL34-AS1 had lower expression levels in gastric cancer tissues than the normal counterparts. In gastric cell lines, the three lncRNAs were also down-regulated compared with the respective normal gastric epithelial cell line GES-1. Moreover, the low expression levels of DKFZP434K028 and RPL34-AS1 positively correlated with the larger tumor size. 26237576 Lnc2Cancer
pancreatic cancer qPCR, Western blot, knockdown etc. PDAC tissue down-regulated expression The upregulation of LINC00152 (MACE log2fc: 2.3, qPCR: 1.5) and downregulation of LINC00261 (MACE log2fc: 5.3, qPCR: 4.4) in PDAC tissues was confirmed by qPCR. 25910082 Lnc2Cancer
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
RNA-seq, knockdown human endoderm and pancreatic cells N/A Interaction DEANR1 contributes to endoderm differentiation by positively regulating expression of the endoderm factor FOXA2. Mechanistically, DEANR1 facilitates FOXA2 activation by facilitating SMAD2/3 recruitment to the FOXA2 promoter. 25843708
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
FOXA2 RNA-DNA regulation Mechanistically, DEANR1 facilitates FOXA2 activation by facilitating SMAD2/3 recruitment to the FOXA2 promoter. 25843708