LncRNA Information
ID	EL0619	Name	IRAIN	Aliases	IGF1R-AS
Species	Homo sapiens	Chromosome	15	Start site	98646951
End site	98647371	Chain	minus	Exon NO.	1
Assembly	Ensembl Release 89	Class	antisense	NCBI accession	NR_126453
Ensembl	ENSG00000259424	Sequence

Disease
Disease	Method	Sample	Expression pattern	Dysfunction type	Description	PMID	Source
non small cell lung cancer	knockdown	non-small cell lung cancer (NSCLC) tissues	up-regulated	expression	Knockdown of IRAIN suppressed NSCLC cells proliferation in vitro.	26722412
breast cancer	qPCR etc.	breast cancer tissue	down-regulated	locus	In breast cancer tissues, we found that IRAIN lncRNA was transcribed from an intronic promoter in an antisense diretcion as compared to the IGF1R coding mRNA. Unlike the IGF1R coding RNA, this non-coding RNA was imprinted, with monoallelic expression from the paternal allele. IRAIN was aberrantly imprinted in both tumours and peripheral blood leucocytes, exhibiting a pattern of allele-switch: the allele expressed in normal tissues was inactivated and the normally imprinted allele was expressed.	25465188	Lnc2Cancer
acute myeloid leukemia	qPCR, Northern blot, in vitro knockdown, ChIP etc.	blood, cell lines (K562, KG-1, KG-1a, HL60, TF1)	down-regulated	interaction	We demonstrate that this lncRNA interacts with chromatin DNA and is involved in the formation of an intrachromosomal enhancer/promoter loop. In addition, IRAIN was downregulated both in leukemia cell lines and in blood obtained from high-risk AML patients. Activating the IGF1R gene, lead to growth advantage and tumor progression.	25092925	Lnc2Cancer

Interaction
Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
chromatin DNA	RNA-DNA	regulation	this lncRNA interacts with chromatin DNA and is involved in the formation of an intrachromosomal enhancer/promoter loop.	25092925