| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0587 | Name | HOXA-AS | Aliases | CG7895; DmelCG7895; DmNK-4; DROHOXHK4; DROHOXNK4; HOX; msh-2; msh2; NK-4; NK-4/msh-2; NK4; NK4/msh-2; NKX2.5; Tin; TIN; tin/NK4 | |
| Species | Homo sapiens | Chromosome | N/A | Start site | N/A | |
| End site | N/A | Chain | N/A | Exon NO. | N/A | |
| Assembly | N/A | Class | lincRNA | NCBI accession | N/A | |
| Ensembl | N/A | Sequence | N/A | |||
| Function (not disease relevant) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
| PCR | heart, lung, liver, kidney, colon, placenta, muscle, and brain | N/A | expression | This noncoding transcription is regulated by the retinoic acid morphogen and follows the colinear activation pattern of the cluster. Opening of the cluster at sites of activation of intergenic transcripts is accompanied by changes in histone modifications and a loss of interaction with Polycomb group (PcG) repressive complexes. | 17185360 | ||||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| HOXA gene | RNA-DNA | regulation | We have investigated the intergenic, noncoding transcriptomes of mammalian HOX clusters. We show that "opposite strand transcription" from the intergenic spacer regions in the human HOXA cluster correlates with the activity state of adjacent HOXA genes. This noncoding transcription is regulated by the retinoic acid morphogen and follows the colinear activation pattern of the cluster. Opening of the cluster at sites of activation of intergenic transcripts is accompanied by changes in histone modifications and a loss of interaction with Polycomb group (PcG) repressive complexes. | 17185360 | |||||