LncRNA Information
ID EL0580 Name HOTAIRM1 Aliases HOXA-AS1; HOXA1-AS1; NCRNA00179
Species Homo sapiens Chromosome 7 Start site 27095647
End site 27100265 Chain plus Exon NO. 3
Assembly Ensembl Release 89 Class antisense NCBI accession NR_038366, NR_038367
Ensembl ENSG00000233429 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
acute myeloid leukemia N/A 241 AML patients, 215 intermediate-risk AML (IR-AML) patients N/A interaction In 215 IR-AML patients, high HOTAIRM1 expression was independently associated with shorter overall survival (OR:2.04;P = 0.001), shorter leukemia-free survival (OR:2.56; P < 0.001) and a higher cumulative incidence of relapse (OR:1.67; P = 0.046). HOTAIRM1 was overexpressed in NPM1-mutated AML (P < 0.001) and within this group retained its prognostic value (OR: 2.21; P = 0.01). miR-196b and HOTAIRM1 in combination as a prognostic factor can classify patients as high-, intermediate-, or low-risk (5-year OS: 24% vs 42% vs 70%; P = 0.004). 26433964
pancreatic ductal adenocarcinoma N/A pancreatic ductal adenocarcinoma (PDAC) tissues up-regulated expression The expression level of long intergenic non-coding RNA HOTAIRM1 was upregulated in 12 PDAC tissues samples compared with matched adjacent non-tumor samples by qRT-PCR. The revelation of an association between HOTAIRM1 expression and PDAC is especially noteworthy. 26676849
acute promyelocytic leukemia qPCR, knockdown etc. cell lines (NB4, HEK293) up-regulated N/A HOTAIRM1 is Highly expressed and provides a regulatory link in myeloid maturation by modulating integrin-controlled cell cycle progression at the gene expression level. 24824789 Lnc2Cancer
promyelocytic leukemia qPCR, knockdown etc. cell lines (NB4 and HEK293) down-regulated N/A HOTAIRM1 knockdown resulted in retained expression of many otherwise ATRA-suppressed cell cycle and DNA replication genes, and abated ATRA induction of cell surface leukocyte activation, defense response, and other maturation-related genes. Resistance to ATRA-induced cell cycle arrest at the G1/S phase transition in knockdown cells was accompanied by retained expression of ITGA4 (CD49d) and decreased induction of ITGAX (CD11c). The coupling of cell cycle progression with temporal dynamics in the expression patterns of these integrin genes suggests a regulated switch to control the transit from the proliferative phase to granulocytic maturation. Furthermore, ITGAX was among a small number of genes showing perturbation in transcript levels upon HOTAIRM1 knockdown even without ATRA treatment, suggesting a direct pathway of regulation 24824789 Lnc2Cancer
infiltrating ductal carcinomas RNA-seq, qRT-PCR human mammary epithelial cells (non-transformed) and the breast cancer cell line MCF-7 up-regulated expression The lncRNA HOTAIRM1 was significantly overexpressed in the basal-like subgroup. 25296969
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
sucrose gradient analysis N/A up-regulated expression Knockdown of HOTAIRM1 quantitatively blunted RA-induced expression of HOXA1 and HOXA4 during the myeloid differentiation of NB4 cells, and selectively attenuated induction of transcripts for the myeloid differentiation genes CD11b and CD18, but did not noticeably impact the more distal HOXA genes. 19144990
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
HOXA1 and HOXA4 RNA-DNA regulation Knockdown of HOTAIRM1 quantitatively blunted RA-induced expression of HOXA1 and HOXA4 during the myeloid differentiation of NB4 cells, and selectively attenuated induction of transcripts for the myeloid differentiation genes CD11b and CD18, but did not noticeably impact the more distal HOXA genes. 19144990
HOXA1 RNA-RNA co-expression HOTAIRM1 knockdown in NB4 cells prevented RA induction of HOXA1 and A4. 21874119 LncRNADisease
HOXA4 RNA-RNA co-expression HOTAIRM1 knockdown in NB4 cells prevented RA induction of HOXA1 and A4. 21874119 LncRNADisease
miR-196b DNA-RNA co-expression HOTAIRM1 expression was associated with a specific 33-microRNA signature that included miR-196b (P < 0.001). 26433964