LncRNA Information
ID EL0579 Name Hotair Aliases Gm16258; OTTMUSG00000032781
Species Mus musculus Chromosome 15 Start site 102944062
End site 102947730 Chain minus Exon NO. 2
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_047528
Ensembl ENSMUSG00000086903 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
homeotic transformation of the spine and malformation of metacarpal-carpal bone knockdown, RNA-sequencing N/A N/A interaction Targeted deletion of mouse Hotair lncRNA leads to derepression of hundreds of genes, resulting in homeotic transformation of the spine and malformation of metacarpal-carpal bones. 24075995
 


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
N/A N/A N/A N/A regulate HOXD genes in trans via the recruitment of Polycomb Repressive Complex 2 (PRC2), followed by the trimethylation of lysine 27 of histone H3. 21637793
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
HOXD genes RNA-DNA regulation We show that the cognate mouse Hotair is poorly conserved in sequence; and its absence, along with the deletion of the HoxC cluster, has surprisingly little effect in vivo, neither on the expression pattern or transcription efficiency, nor on the amount of K27me3 coverage of different Hoxd target genes. 21637793
Polycomb repressive complex 2 and Lsd1 complex RNA-Protein binding Hotair binds to both Polycomb repressive complex 2, which methylates histone H3 at lysine 27 (H3K27), and Lsd1 complex, which demethylates histone H3 at lysine 4 (H3K4) in vivo. Hotair inactivation causes H3K4me3 gain and, to a lesser extent, H3K27me3 loss at target genes. 24075995
HoxD RNA-DNA regulation RNA sequencing and conditional inactivation reveal an ongoing requirement of Hotair to repress HoxD genes and several imprinted loci such as Dlk1-Meg3 and Igf2-H19 without affecting imprinting choice. 24075995