LncRNA Information
ID EL0561 Name HAR1A Aliases HAR1F; LINC00064; NCRNA00064
Species Homo sapiens Chromosome 20 Start site 63101292
End site 63104385 Chain plus Exon NO. 2
Assembly GRCh38.p7 Class N/A NCBI accession NR_003244
Ensembl N/A Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
Huntington's disease N/A N/A N/A expression HAR1, a deeply conserved genomic region consisting of a cis-antisense pair of structured lncRNAs (HAR1F and HAR1R) (2, 23) located ~80 kb from the neural microRNA, miR-124-3. HAR1 levels are significantly lower in the striatum of HD patients. 20179156 LncRNADisease
Alzheimer's disease N/A N/A N/A N/A Schizophrenia spectrum disorders and AD have also been linked with the rheelin (RELN) gene and its antisense transcript HAR1 22817756 LncRNADisease
schizophrenia N/A N/A N/A N/A Schizophrenia spectrum disorders and AD have also been linked with the rheelin (RELN) gene and its antisense transcript HAR1 22817756 LncRNADisease
Huntington's disease N/A N/A N/A regulation HAR1 has also been implicated in HD, where the transcriptional repressor RE-1-silencing transcription factor (REST) enters pathologically into the nucleus, leading to the repression of several important neuronal genes. 23562612 LncRNADisease
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
RELN DNA-TF regulation The lncRNA HAR1F is transcribed from one of these regions and specifically co-expressed in Cajal-Retzius cells of the human neocortex with the critical neural factor RELN (Pollard et al., 2006), which mediates seminal neural developmental processes and is implicated in the pathophysiology of a broad range of neurological and psychiatric disorders. 20380817 LncRNADisease
REST DNA-TF regulation RNA in-situ hybridization showed that HAR1F is expressed in developing neurons of the human embryonic neocortex, and its expression was recently shown to be regulated by the master neural transcriptional repressor, REST. 20951849 LncRNADisease