| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0552 | Name | GSTT1-AS1 | Aliases | N/A | |
| Species | Homo sapiens | Chromosome | 22 | Start site | 270138 | |
| End site | 270389 | Chain | N/A | Exon NO. | 1 | |
| Assembly | GRCh38.p7 | Class | antisense | NCBI accession | NR_132348 | |
| Ensembl | N/A | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| Mycobacterium tuberculosis infection | knock-down | CD244(+)CD8(+) T-cell line | up-regulated | expression | CD244 expression/signaling in TB correlates with high levels of a long noncoding RNA (lncRNA)-BC050410 [named as lncRNA-AS-GSTT1 (1-72) or lncRNA-CD244] in the CD244(+)CD8(+) T-cell subpopulation. CD244 signaling drives lncRNA-CD244 expression via sustaining a permissive chromatin state in the lncRNA-CD244 locus. | 26150504 | |||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| zeste homolog 2 (EZH2) | RNA-Protein | binding | By recruiting polycomb protein enhancer of zeste homolog 2 (EZH2) to infg/tnfa promoters, lncRNA-CD244 mediates H3K27 trimethylation at infg/tnfa loci toward repressive chromatin states and inhibits IFN-γ/TNF-α expression in CD8(+) T cells | 26150504 | |||||