| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0492 | Name | FENDRR | Aliases | FOXF1-AS1; TCONS_00024240; lincFOXF1; onco-lncRNA-21 | |
| Species | Homo sapiens | Chromosome | 16 | Start site | 86474529 | |
| End site | 86509099 | Chain | minus | Exon NO. | 7 | |
| Assembly | Ensembl Release 89 | Class | lincRNA | NCBI accession | NR_033925, NR_036444 | |
| Ensembl | ENSG00000268388 | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| Xuanwei lung cancer | High throughput microarray assay, qRT-PCR | Xuanwei lung cancer (XWLC) tissues | N/A | expression | N/A | 26642714 | |||
| gastric cancer | qPCR, Western blot etc. | gastric cancer tissue, cell lines (MGC803, BGC823, MKN28, MKN45, SGC7901) | down-regulated | interaction | FENDRR was downregulated in gastric cancer cell lines and cancerous tissues, as compared with normal gastric epithelial cells and adjacent noncancerous tissue samples. Low FENDRR expression was correlated with deeper tumor invasion, higher tumor stage, and lymphatic metastasis. Histone deacetylation was involved in the downregulation of FENDRR in gastric cancer cells. FENDER overexpression suppressed invasion and migration by gastric cancer cells in vitro, by downregulating FN1 and MMP2/MMP9 expression. | 25167886 | Lnc2Cancer | ||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| PRC2 | RNA-Protein | binding | Numerous lincRNAs are physically associated with PRC2. | 19571010 | LncRNADisease | ||||
| FN1 and MMP2/MMP9 | RNA-Protein | regulation | FENDER overexpression suppressed invasion and migration by gastric cancer cells in vitro, by downregulating FN1 and MMP2/MMP9 expression. | 25167886 | |||||