LncRNA Information
ID EL0484 Name EWSAT1 Aliases LINC00277; NCRNA00277; TMEM84
Species Homo sapiens Chromosome 15 Start site 69072926
End site 69095820 Chain plus Exon NO. 4
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_026949
Ensembl ENSG00000212766 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
Ewing sarcoma microarray, qPCR, Western blot, RIP etc. cell lines (pMPCs, PSS090 and TC71) up-regulated regulation Expression of EWS-FLI1 and EWSAT1 repressed gene expression, and a substantial fraction of targets that were repressed by EWS-FLI1 were also repressed by EWSAT1. Analysis of RNAseq data from primary human Ewing sarcoma further supported a role for EWSAT1 in mediating gene repression. We identified heterogeneous nuclear ribonucleoprotein (HNRNPK) as an RNA-binding protein that interacts with EWSAT1 and found a marked overlap in HNRNPK-repressed genes and those repressed by EWS-FLI1 and EWSAT1, suggesting that HNRNPK participates in EWSAT1-mediated gene repression. 25401475 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
heterogeneous nuclear ribonucleoprotein (HNRNPK) RNA-Protein binding heterogeneous nuclear ribonucleoprotein (HNRNPK) as an RNA-binding protein that interacts with EWSAT1 25401475