| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0349 | Name | DLX6-AS1 | Aliases | DLX6-AS; DLX6AS; Evf-2; NCRNA00212 | |
| Species | Homo sapiens | Chromosome | 7 | Start site | 96955141 | |
| End site | 97014065 | Chain | minus | Exon NO. | 3 | |
| Assembly | Ensembl Release 89 | Class | antisense | NCBI accession | NR_015448 | |
| Ensembl | ENSG00000231764 | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| lung adenocarcinoma | microarray, qPCR, Western blot etc. | lung cancer tissue, cell lines(A549, H1650 etc.) | up-regulated | expression | The expression level of lncRNA DLX6-AS1 in LAC tissues was significantly higher compared to paired adjacent normal lung tissues. In addition, its expression level was closed correlated with both histological differentiation and TNM stage. Down-regulation of lncRNA DLX6-AS1 expression decreased the DLX6 mRNA and protein levels. | 26052251 | Lnc2Cancer | ||
| Split Hand/Split Foot malformation disorder | N/A | N/A | N/A | Interaction | The lncRNA EVF2, which recruits the transcription factor Dlx2 to activate the protein coding genes DLX5 and DLX6 that are associated with the Split Hand/ Split Foot malformation disorder. | 20930520 | LncRNADisease | ||
| Function (not disease relevant) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
| N/A | N/A | N/A | locus | the Evf-2 ncRNA activates transcriptional activity by directly influencing Dlx-2 activity | 16705037 | ||||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| Dlx-2 | RNA-Protein | regulation | Evf-2 specifically cooperates with Dlx-2 to increase the transcriptional activity of the Dlx-5/6 enhancer in a target and homeodomain-specific manner. A stable complex containing the Evf-2 ncRNA and the Dlx-2 protein forms in vivo, suggesting that the Evf-2 ncRNA activates transcriptional activity by directly influencing Dlx-2 activity. These experiments identify a novel mechanism whereby transcription is controlled by the cooperative actions of an ncRNA and a homeodomain protein. | 16705037 | |||||
| Dlx-5 | DNA-DNA | regulation | Evf2 is a long, polyadenylated ncRNA transcribed from an ultraconserved intergenic enhancer region associated with the Dlx-5/6 locus. | 20573714 | LncRNADisease | ||||
| Dlx-6 | DNA-DNA | regulation | Evf2 is a long, polyadenylated ncRNA transcribed from an ultraconserved intergenic enhancer region associated with the Dlx-5/6 locus. | 20573714 | LncRNADisease | ||||