| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0333 | Name | DBH-AS1 | Aliases | NCRNA00118 | |
| Species | Homo sapiens | Chromosome | 9 | Start site | 133654586 | |
| End site | 133657313 | Chain | minus | Exon NO. | 2 | |
| Assembly | Ensembl Release 89 | Class | antisense | NCBI accession | NR_102735 | |
| Ensembl | ENSG00000225756 | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| hepatocelluar carcinoma | qPCR, Western blot, knockdown etc. | HCC tissue, cell lines (HepG2, SMMC-7721, Hep3B, MHCC97H, SK-Hep1) | up-regulated | interaction | The levels of DBH-AS1 were positively correlated with hepatitis B surface antigen (HBsAg) and tumor size in HCC tissues. Overexpression of DBH-AS1 induced cell cycle progression by accelerating G1/S and G2/M transition concomitantly with upregulation of CDK6, CCND1, CCNE1 and downregulation of p16, p21 and p27. We also provide evidence that DBH-AS1 could be significantly induced by HBx protein and markedly down-regulated by p53. Thus, we concluded that DBH-AS1 can be induced by HBx and inactivated by p53, and consequently promote cell proliferation and cell survival through activation of MAPK signaling in HCC. | 26393879 | Lnc2Cancer | ||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| hepatitis B virus x protein (HBx) | RNA-Protein | regulation | DBH-AS1 could be significantly induced by HBx protein and markedly down-regulated by p53. | 26393879 | |||||
| p53 | RNA-Protein | regulation | DBH-AS1 could be significantly induced by HBx protein and markedly down-regulated by p53. | 26393879 | |||||
| MAPK signaling | N/A | regulation | DBH-AS1 was shown to activate MAPK pathway. | 26393879 | |||||
| CDK6, CCND1, CCNE1 | RNA-Protein | regulation | Overexpression of DBH-AS1 induced cell cycle progression by accelerating G1/S and G2/M transition concomitantly with upregulation of CDK6, CCND1, CCNE1 and downregulation of p16, p21 and p27. | 26393879 | |||||
| p16, p21 and p27 | RNA-Protein | regulation | Overexpression of DBH-AS1 induced cell cycle progression by accelerating G1/S and G2/M transition concomitantly with upregulation of CDK6, CCND1, CCNE1 and downregulation of p16, p21 and p27. | 26393879 | |||||