LncRNA Information
ID EL0301 Name CPS1-IT1 Aliases CPS1-IT; CPS1IT; CPS1IT1; PRO0132
Species Homo sapiens Chromosome 2 Start site 210617571
End site 210619876 Chain plus Exon NO. 1
Assembly Ensembl Release 89 Class sense intronic NCBI accession NR_002763
Ensembl ENSG00000280837 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
intrahepatic cholangiocarcinoma qPCR, Western blot, knockdown, Flow cytometry assay etc. ICC tissue, cell line(L-02, Huh-7, Bel-7402) up-regulated interaction Carbamoyl-phosphate synthase 1 (CPS1) and its lncRNA CPS1 intronic transcript 1 (CPS1-IT1) were observed to be upregulated in ICC. CPS1 and CPS1-IT1 were co-upregulated in ICC tissues compared with non-cancerous tissues. Knockdown of CPS1 andor CPS1-IT1 reduced the proliferation and increased the apoptosis of ICC-9810 cells. Additionally, clinical analysis indicated that CPS1 and CPS1-IT1 were associated with poor liver function and reduced survival rates when the relative expression values were greater than 4 in cancer tissues. 26499888 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
CPS1 RNA-Protein co-expression CPS1 and CPS1‑IT1 were co‑upregulated in ICC tissues compared with non‑cancerous tissues. 26499888