| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL0283 | Name | CCEPR | Aliases | CCHE1; lncRNA-CCHE1 | |
| Species | Homo sapiens | Chromosome | 10 | Start site | 59173963 | |
| End site | 59176464 | Chain | minus | Exon NO. | 1 | |
| Assembly | GRCh38.p7 | Class | N/A | NCBI accession | NR_131782 | |
| Ensembl | N/A | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| cervical cancer | qPCR, Western blot, knockdown, RNA pull-down assay etc. | cervical cancer tissue, cell lines (HeLa, SiHa) | up-regulated | interaction | In this study, we found that cervical carcinoma high-expressed lncRNA 1 (lncRNA-CCHE1) was significantly upregulated in cervical cancer tissues. The higher expression of CCHE1 was significantly correlated with large tumor size, advanced Federation of Gynecology and Obstetrics stage, uterine corpus invasion, and poor survival. CCHE1 plays a pivotal role in cervical cancer cell proliferation via increasing PCNA expression and serves as a potential prognostic biomarker and therapeutic target in human cervical cancer. | 25921283 | Lnc2Cancer | ||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| PCNA | RNA-DNA | regulation | RNA pull-down assays confirmed that CCHE1 physically associates with proliferating cell nuclear antigen (PCNA) messenger RNA, consequently enhances the expression of PCNA. The expression of CCHE1 and PCNA is significantly correlated in cervical cancer tissues. | 25921283 | |||||