LncRNA Information
ID	EL0249	Name	BRCA1	Aliases	BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Species	Homo sapiens	Chromosome	17	Start site	43044295
End site	43170245	Chain	minus	Exon NO.	24
Assembly	Ensembl Release 89	Class	retained intron	NCBI accession	NR_027676
Ensembl	ENSG00000012048	Sequence

Function (not disease relevant)
Methods	Sample/condition	Expression pattern	Dysfunction type	Description	PMID	Source
knockdown	human fibroblast cells	N/A	expression	Gene expression analysis after RNAi treatment targeted against DDSR1 revealed 119 genes that show differential expression.	26697398
microarray, qRT-PCR	N/A	N/A	interaction	Loss of DDSR1 impairs cell proliferation and DDR signaling and reduces DNA repair capacity by homologous recombination (HR). The HR defect in the absence of DDSR1 is marked by aberrant accumulation of BRCA1 and RAP80 at DSB sites.	26411689

Interaction
Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
BRCA1	RNA-DNA	regulation	In line with a role in regulating HR, DDSR1 interacts with BRCA1 and hnRNPUL1, an RNA-binding protein involved in DNA end resection.	26411689
hnRNPUL1	RNA-Protein	regulation	In line with a role in regulating HR, DDSR1 interacts with BRCA1 and hnRNPUL1, an RNA-binding protein involved in DNA end resection.	26411689