LncRNA Information
ID EL0244 Name BLACAT1 Aliases LINC00912; linc-UBC1; onco-lncRNA-30
Species Homo sapiens Chromosome 1 Start site 205434886
End site 205437879 Chain minus Exon NO. 2
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_103783
Ensembl ENSG00000281406 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
bladder cancer microarray, qPCR, knockdown, ISH etc. bladder cancer tissue, cell lines (J82, UMUC-3, HT-1376, T24, 5637 etc.) up-regulated N/A qPCR confirmed that linc-UBC1 expression is up-regulated in 60 cases (58.8%) in bladder cancer tissues compared with normal adjacent tissues, and its overexpression correlates with lymph node metastasis and poor survival. Further functional analysis demonstrated that knockdown of linc-UBC1 attenuates bladder cancer cell proliferation, motility, invasion, colony formation ability, tumorigenicity and metastatic potential. RIP and ChIP assay confirmed that linc-UBC1 physically associates with PRC2 complex and regulates histone modification status of target genes. 23688781 Lnc2Cancer
bladder cancer N/A N/A N/A expression Theseguilty by association studies have found numerous bladder-cancer associated lncRNAs 24006935 LncRNADisease
gastric cancer qPCR, knockdown etc. gastric cancer tissue, cell lines (BGC-823, SGC-7901, AGS, MKN-45, HGC-27 etc.) up-regulated expression We found that linc-UBC1 was significantly upregulated in gastric cancer tissues compared to adjacent normal tissues. Furthermore, high linc-UBC1 expression was associated with lymph-node metastasis, tumor size, TNM stage and poorer prognosis. Inhibition of linc-UBC1 suppressed the proliferation, motility and invasion of gastric cancer cells.Inhibition of linc-UBC1 suppressed the proliferation, motility and invasion of gastric cancer cells. 25755750 Lnc2Cancer