LncRNA Information
ID	EL0226	Name	BALR-6	Aliases	N/A
Species	Homo sapiens	Chromosome	N/A	Start site	N/A
End site	N/A	Chain	N/A	Exon NO.	N/A
Assembly	N/A	Class	N/A	NCBI accession	N/A
Ensembl	N/A	Sequence	N/A

Disease
Disease	Method	Sample	Expression pattern	Dysfunction type	Description	PMID	Source
B-lymphoblastic leukemia	qPCR, Northern blot, knockdown etc.	cell lines(MV, Reh, 697, Nalm-6, 70Z/3, HEK 293)	up-regulated	interaction	Overexpression of BALR-6 in murine bone marrow transplantation experiments caused a significant increase in early hematopoietic progenitor populations, suggesting that its dysregulation may cause developmental changes. Notably, the knockdown of BALR-6 resulted in global dysregulation of gene expression. The gene set was enriched for leukemia-associated genes, as well as for the transcriptome regulated by Specificity Protein 1 (SP1). We confirmed changes in the expression of SP1, as well as its known interactor and downstream target CREB1. Luciferase reporter assays demonstrated an enhancement of SP1-mediated transcription in the presence of BALR-6. These data provide a putative mechanism for regulation by BALR-6 in B-ALL	26694754	Lnc2Cancer

Interaction
Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
Specificity Protein 1 (SP1)	RNA-Protein	regulation	An enhancement of SP1-mediated transcription in the presence of BALR-6.	26694754