| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL1532 | Name | APELA | Aliases | ELA, Ende, tdl | |
| Species | Homo sapiens | Chromosome | 4 | Start site | 164877004 | |
| End site | 164898965 | Chain | plus | Exon NO. | 4 | |
| Assembly | Ensembl Release 89 | Class | N/A | NCBI accession | NM_001297550, XM_017007623 | |
| Ensembl | ENSG00000248329 | Sequence | ||||
| Function (not disease relevant) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
| RNA-Seq, Rescue and overexpression, knockdown, In situ hybridization | N/A | N/A | interaction | Toddler is annotated as a non-coding RNA in zebrafish (ENSDARG00000094729), mouse [Gm10664; also called Ende], and human (LOC100506013) and is present in two lncRNA catalogs; however, it contains a 58–amino acid ORF with a predicted signal sequence and high conservation in vertebrates, including human. Local and ubiquitous production of Toddler promote cell movement, suggesting that Toddler is neither an attractant nor a repellent but acts globally as a motogen. | 26387754, 25639753, 20153842, 24316148, 24407481 | ||||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| APJ/Apelin receptors | Peptide-Protein | regulation | Toddler drives internalization of G protein–coupled APJ/Apelin receptors, and activation of APJ/Apelin signaling rescues toddler mutants. | 26387754, 25639753, 20153842, 24316148, 24407481 | |||||