LncRNA Information
ID EL1512 Name XRN1 Aliases YGL173C; DST2; KEM1; RAR5; SEP1; SKI1
Species Saccharomyces cerevisiae S288c Chromosome VII Start site 175527
End site 180113 Chain minus Exon NO. 1
Assembly Build 3.1 Class antisense NCBI accession N/A
Ensembl N/A Sequence N/A


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
RNA-seq, qRT-PCR yeast N/A N/A The majority of XUTs strongly accumulate in lithium-containing media, indicating that they might have a role in adaptive responses to changes in growth conditions. Notably, RNAPII chromatin immunoprecipitation followed by DNA sequencing (ChIP-seq) analysis of Xrn1-deficient strains revealed a significant decrease of RNAPII occupancy over273 genes with antisense XUTs. These genes show an unusual bias for H3K4me3 marks and require the Set1 histone H3 lysine 4 methyl-transferase for silencing. Furthermore, abolishing H3K4me3 triggers the silencing of other genes with antisense XUTs, supporting a model in which H3K4me3 antagonizes antisense ncRNA repessive activity. Our results demonstrate that antisense ncRNA-mediated regulation is a general regulatory pathway for gene expression in S. cerevisiae. 21697827