LncRNA Information
ID EL1442 Name Vax2os Aliases Vas2os1; Vax2os2; Vax2os
Species Mus musculus Chromosome 6 Start site 83692806
End site 83712201 Chain minus Exon NO. 7
Assembly Ensembl Release 89 Class antisense NCBI accession NR_002871, NR_002873, NR_075094, NR_075095
Ensembl ENSMUSG00000085794 Sequence


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
N/A photoreceptor progenitors in the mouse retina N/A N/A regulate cell cycle in the mammalian retina during development. the overexpression of Vax2os1 in the developing early postnatal mouse retina causes an impaired cell cycle progression of photoreceptor rogenitors toward their final committed fate and a consequent delay of their differentiation processes. At later developmental stages, this perturbation is accompanied by an increase of apoptotic events in the photoreceptor cell layer, in comparison with control retinas, without affecting the proper cell layering in the adult retina. Similar results are observed in mouse photoreceptor-derived 661W cells in which Vax2os1 overexpression results in an impairment of the cell cycle progression rate and cell differentiation. 22128341
RT-PCR and RNA in situ hybridization retina N/A interaction We found a significant reduction of the expression levels of one of these nats, vax2os (vax2 opposite strand) in a mouse mutant carrying the inactivation of vax2, the corresponding sense gene. 15703187
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
Vax2 RNA-DNA regulation We found a significant reduction of the expression levels of one of these nats, vax2os (vax2 opposite strand) in a mouse mutant carrying the inactivation of vax2, the corresponding sense gene. 15703187
Crx DNA-TF regulation Vax2OS was independently identified as a transcriptional target of both Crx and Nrl in a recent microarray-based screen. 19191220 LncRNADisease
Nrl DNA-TF regulation Vax2OS was independently identified as a transcriptional target of both Crx and Nrl in a recent microarray-based screen. 19191220 LncRNADisease