LncRNA Information
ID	EL0014	Name	AATBC	Aliases	N/A
Species	Homo sapiens	Chromosome	21	Start site	43805758
End site	43812567	Chain	minus	Exon NO.	2
Assembly	Ensembl Release 89	Class	antisense	NCBI accession	NR_026961
Ensembl	ENSG00000215458	Sequence

Disease
Disease	Method	Sample	Expression pattern	Dysfunction type	Description	PMID	Source
bladder cancer	microarray, qPCR, in vitro knockdown etc.	bladder cancer tissue	up-regulated	interaction	We found that AATBC was overexpressed in bladder cancer patient tissues and positively correlated with tumor grade and pT stage. We also found that inhibition of AATBC resulted in cell proliferation arrest through G1 cell cycle mediated by cyclin D1, CDK4, p18 and phosphorylated Rb. In addition, inhibition of AATBC induced cell apoptosis through the intrinsic apoptosis signaling pathway, as evidenced by the activation of caspase-9 and caspase-3. The investigation for the signaling pathway revealed that the apoptosis following AATBC knockdown was mediated by activation of phosphorylated JNK and suppression of NRF2.	25473900	Lnc2Cancer

Interaction
Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
JNK, NRF2	RNA-DNA	regulation	The apoptosis following AATBC knockdown was mediated by activation of phosphorylated JNK and suppression of NRF2.	25473900