LncRNA Information
ID EL1369 Name Tsix Aliases N/A
Species Mus musculus Chromosome X Start site 103431517
End site 103484957 Chain plus Exon NO. 4
Assembly Ensembl Release 89 Class antisense NCBI accession NR_002844
Ensembl ENSMUSG00000085715 Sequence


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
N/A mouse embryonic epiblasts, epiblast stem cells, and embryonic stem cells N/A mutation Tsix RNA is believed to orchestrate the initiation of X-inactivation, influencing the choice of which X remains active by preventing expression of the antisense Xist RNA, which is required to silence the inactive-X. 25981039
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
XIST RNA-DNA regulation Tsix directly regulates its transcription. 16507360 LncRNADisease
41186 RNA-Protein binding Oct4 directly binds Tsix and Xite, two regulatory noncoding RNA genes of the X-inactivation centre, and also complexes with XCI trans-factors, Ctcf and Yy1. 19536159 LncRNADisease
XIST RNA-RNA regulation For the active X, the antisense Tsix RNA is an established Xist repressor. 21029862 LncRNADisease
XIST RNA-DNA regulation Tsix represses Xist induction by several means, including altering the chromatin state of Xist, deploying Dnmt3a’s DNA methyltransferase activity, recruiting the RNAi machinery, and interfering with the ability of Xist and RepA RNA to engage Polycomb proteins. 21029862 LncRNADisease
XIST RNA-RNA regulation Xist is controlled by two parallel RNA switches – Tsix for Xa and Jpx for Xi. Tsix represses Xist on Xa. 21029862 LncRNADisease
XIST RNA-DNA regulation Epigenetically silences Xist expression by inhibiting RepA recruitment of polycomb complexes to maintain the active X chromosome in females. 21256239 LncRNADisease
RepA RNA-RNA regulation Epigenetically silences Xist expression by inhibiting RepA recruitment of polycomb complexes to maintain the active X chromosome in females. 21256239 LncRNADisease
XIST RNA-DNA regulation Tsix is associated with both enrichment of the H3K4me3 active mark and prevention of the deposition of the repressive mark H3K27me3 within the body of the Xist gene. Tsix, for instance, may be subject to Xist silencing at the onset of XCI. 21329697 LncRNADisease
XIST RNA-RNA regulation The noncoding Tsix RNA is an antisense repressor of Xist and regulates X inactivation in mice. 21852535 LncRNADisease
Xist RNA RNA-RNA regulation Tsix is instead required to silence Xist on the active-X as epiblast cells differentiate in both males and females. 25981039