| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL1368 | Name | TSIX | Aliases | LINC00013; NCRNA00013; XIST-AS; XIST-AS1; XISTAS | |
| Species | Homo sapiens | Chromosome | X | Start site | 73792205 | |
| End site | 73829231 | Chain | plus | Exon NO. | 1 | |
| Assembly | Ensembl Release 89 | Class | lincRNA | NCBI accession | NR_003255 | |
| Ensembl | ENSG00000270641 | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| systemic sclerosis | real-time PCR and in situ hybridization, immunoblotting | dermal fibroblasts, serum | up-regulated | interaction | TSIX siRNA reduced the mRNA expression of type I collagen in normal and SSc dermal fibroblasts, but not the levels of major disease-related cytokines. In addition, TSIX siRNA significantly reduced type I collagen mRNA stability, but not protein half-lives. TSIX is a new regulator of collagen expression which stabilizes the collagen mRNA. | 26566700 | |||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| TGF-β | RNA-Protein | regulation | The upregulation of TSIX seen in SSc fibroblasts may result from activated endogenous TGF-β signalling and may play a role in the constitutive upregulation of collagen in these cells. | 26566700 | |||||
| collagen | RNA-RNA | regulation | TSIX is a new regulator of collagen expression which stabilizes the collagen mRNA. | 26566700 | |||||