| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL1366 | Name | TRPM2-AS | Aliases | TRPM2-AS1 | |
| Species | Homo sapiens | Chromosome | 21 | Start site | 44414588 | |
| End site | 44425272 | Chain | minus | Exon NO. | 3 | |
| Assembly | Ensembl Release 89 | Class | antisense | NCBI accession | NR_109964 | |
| Ensembl | ENSG00000230061 | Sequence | ||||
| Disease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Disease | Method | Sample | Expression pattern | Dysfunction type | Description | PMID | Source | ||
| prostate cancer | microarray, qPCR etc. | cell line (PC3) | differential expression | expression | This essential role, coupled to the TRPM2-AS low-expression levels in healthy tissues, makes this ncRNA a suitable therapeutic target for further clinical studies. To get insights into the survival mechanism controlled by this molecule, we ablated its expression in prostate cancer cells and performed a genome-wide analysis of the transcripts differentially regulated in dying cells. | 26484139 | Lnc2Cancer | ||
| prostate cancer | microarray, qPCR, knockdown etc. | prostate cancer tissue, cell lines (PNT1A, PC3 etc.) | up-regulated | N/A | TRPM2-AS is overexpressed in prostate cancer (PCa). The high expression of TRPM2-AS and its related gene signature were found to be linked to poor clinical outcome, with the related gene signature working also independently of the patient's Gleason score. Mechanistically, TRPM2-AS knockdown led to PCa cell apoptosis, with a transcriptional profile that indicated an unbearable increase in cellular stress in the dying cells, which was coupled to cell cycle arrest, an increase in intracellular hydrogen peroxide and activation of the sense TRPM2 gene. | 24931166 | Lnc2Cancer | ||