LncRNA Information
ID EL1326 Name TGFB2-OT1 Aliases N/A
Species Homo sapiens Chromosome 1 Start site 218442626
End site 218443996 Chain plus Exon NO. 1
Assembly Ensembl Release 89 Class 3prime overlapping ncRNA NCBI accession NR_125715
Ensembl ENSG00000281453 Sequence


Function (not disease relevant)
Methods Sample/condition Expression pattern Dysfunction type Description PMID Source
microarray, RNA interference, RNA-chiP assay, bioinformatics, luciferase reporter assay N/A N/A interaction The protein level of MAP1LC3B-II was greatly increased in HUVECs with FLJ11812 overexpression.FLJ11812 could bind with MIR4459 targeting ATG13 (autophagy-related 13), and ATG13 protein level was decreased along with 3BDO-decreased FLJ11812 level. 25437332
miRNA chip assay, overexpression, 3BDO vascular endothelial cells (VECs) N/A interaction TGFB2-OT1 regulated the levels of 3 microRNAs, MIR3960, MIR4488 and MIR4459. TGFB2-OT1 acted as a competing endogenous RNA, bound to MIR3960, MIR4488 and MIR4459, then regulated the expression of the miRNA targets CERS1 (ceramide synthase 1), NAT8L (N-acetyltransferase 8-like [GCN5-related, putative]), and LARP1 (La ribonucleoprotein domain family, member 1). TGFB2-OT1 increased the LARP1 level, which promoted SQSTM1 (sequestosome 1) expression, NFKB RELA and CASP1 activation, and then production of IL6, IL8 and IL1B in VECs. 26565952
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
MIR4459 RNA-RNA binding FLJ11812 could bind with MIR4459 targeting ATG13 (autophagy-related 13), and ATG13 protein level was decreased along with 3BDO-decreased FLJ11812 level. 25437332
MIR3960, MIR4488 and MIR4459 RNA-RNA binding TGFB2-OT1 acted as a competing endogenous RNA, bound to MIR3960, MIR4488 and MIR4459 26565952