LncRNA Information
ID	EL1225	Name	SNHG15	Aliases	C7orf40; Linc-Myo1g; MYO1GUT
Species	Homo sapiens	Chromosome	7	Start site	44983023
End site	44986961	Chain	minus	Exon NO.	5
Assembly	Ensembl Release 89	Class	lincRNA	NCBI accession	NR_003697
Ensembl	ENSG00000232956	Sequence

Disease
Disease	Method	Sample	Expression pattern	Dysfunction type	Description	PMID	Source
gastric cancer	qPCR, Western blot, knockdown etc.	gastric adenocarcinoma cancer cell lines (SGC7901, BGC823, MGC803, AGS, MKN45, GES-1)	up-regulated	interaction	We identified a novel lncRNA SNHG15, whose expression was upregulated in tumor tissues in 106 patients with gastric cancer (GC) compared with those in the adjacent normal tissues (P < 0.001). Furthermore, increased SNHG15 expression was positively correlated with invasion depth (P < 0.001), advanced tumor node metastasis (TNM) stage (P = 0.001), and lymph node metastasis (P = 0.019). SNHG15 levels were robust in differentiating GC tissues from controls (area under the curve (AUC) = 0.722; 95 % confidence interval (CI) = 0.657-0.782, P < 0.01). Kaplan-Meier analysis demonstrated that elevated SNHG15 expression contributed to poor overall survival (P < 0.01) and disease-free survival (P < 0.01) of patients. A multivariate survival analysis also indicated that SNHG15 could be an independent prognostic marker. Furthermore, knockdown of SNHG15 expression by siRNA could inhibit cell proliferation and invasion and induce apoptosis, while ectopic expression of SNHG15 promoted cell proliferation and invasion in GC cells partly via regulating MMP2 and MMP9 protein expression	26662309	Lnc2Cancer

Interaction
Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
MMP2/MMP9	RNA-Protein	regulation	Ectopic expression of SNHG15 promoted cell proliferation and invasion in GC cells partly via regulating MMP2 and MMP9 protein expression.	26662309