LncRNA Information
ID	EL1223	Name	SNHG12	Aliases	ASLNC04080; C1orf79; LINC00100; NCRNA00100
Species	Homo sapiens	Chromosome	1	Start site	28578538
End site	28582983	Chain	minus	Exon NO.	6
Assembly	Ensembl Release 89	Class	antisense	NCBI accession	NR_024127
Ensembl	ENSG00000197989	Sequence

Disease
Disease	Method	Sample	Expression pattern	Dysfunction type	Description	PMID	Source
endometrial cancer	microarray, qPCR etc.	endometrial carcinoma tissue	up-regulated	expression	ASLNC04080 was the most significantly upregulated lncRNA in microarray data, highly expressed in 22 out of 24 endometrial carcinoma tissues and HEC-1-B cell line. Moreover, the ASLNC04080 lncRNA expression was correlated with 19 coding genes, and may contribute to endometrial carcinoma genesis and progression by co-regulating with coding gene. Expression inhibition of lncRNA ASLNC04080 in HEC-1-B cells caused repression of cell proliferation, increased cell apoptosis, and G1 phase arrest.	25695231	Lnc2Cancer
osteosarcoma	western blot, quantitative real-time polymerase chain reaction, RNA interference, cell migration assays, flow cytometry	primary osteosarcoma (n = 20) and adjacent normal tissues (n = 20), the osteosarcoma cell lines, SAOS-2, MG-63, U-2 OS, and the human osteoblast cell line hFOB (OB3)	up-regulated	interaction	Upregulation of AMOT mRNA was associated with upregulation of SNHG12. Knockdown of SNHG12 reduced the expression of angiomotin in osteosarcoma cells and suppressed cell proliferation and migration but did not affect cell apoptosis. The lncRNA SNHG12 promotes cell proliferation and migration by upregulating AMOT gene expression in osteosarcoma cells in vivo and in vitro.	26486328

Interaction
Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
AMOT	RNA-DNA	regulation	Upregulation of AMOT mRNA was associated with upregulation of SNHG12. The lncRNA SNHG12 promotes cell proliferation and migration by upregulating AMOT gene expression in osteosarcoma cells in vivo and in vitro.	26486328