LncRNA Information
ID	EL1129	Name	RNY1	Aliases	HY1; Y1
Species	Homo sapiens	Chromosome	7	Start site	148987136
End site	148987248	Chain	minus	Exon NO.	1
Assembly	Ensembl Release 89	Class	N/A	NCBI accession	NR_004391
Ensembl	ENSG00000201098	Sequence

Disease
Disease	Method	Sample	Expression pattern	Dysfunction type	Description	PMID	Source
bladder, cervix, colon, kidney, lung and prostate cancer	quantitative RT-PCR,RNA interference	human solid tumour,nonmalignant normal tissues	up-regulated	expression	Degradation of hY1 and hY3 RNAs in human cell lines resulted in a significant cytostatic inhibition of cell proliferation.	18283318

Function (not disease relevant)
Methods	Sample/condition	Expression pattern	Dysfunction type	Description	PMID	Source
Specific degradation	late-G(1)-phase human cells	down-regulated	mutation	Specific degradation of hY RNAs leads to the inhibition of semiconservative DNA replication in late-G(1)-phase template nuclei. This inhibition is negated by resupplementation of hY RNAs. All four hY RNAs (hY1, hY3, hY4, and hY5) can functionally substitute for each other in this system. Mutagenesis of hY1 RNA showed that the binding site for Ro60 protein, which is required for Ro RNP assembly, is not essential for DNA replication. Degradation of hY1 RNA in asynchronously proliferating HeLa cells by RNA interference reduced the percentages of cells incorporating bromodeoxyuridine in vivo.	16943439

Interaction
Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
DNA,Ro60 protein	RNA-DNA	binding	Mutagenesis of hY1 RNA showed that the binding site for Ro60 protein, which is required for Ro RNP assembly, is not essential for DNA replication.	16943439