| LncRNA Information | ||||||
|---|---|---|---|---|---|---|
| ID | EL1117 | Name | Rmrp | Aliases | 1110032O22Rikr; Rmrp | |
| Species | Mus musculus | Chromosome | 4 | Start site | 43492788 | |
| End site | 43493058 | Chain | minus | Exon NO. | 1 | |
| Assembly | Ensembl Release 89 | Class | lincRNA | NCBI accession | NR_001460 | |
| Ensembl | ENSMUSG00000088088 | Sequence | ||||
| Function (not disease relevant) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Methods | Sample/condition | Expression pattern | Dysfunction type | Description | PMID | Source | |||
| N/A | Rmrp gene mutation in mice | N/A | mutation | A targeted Rmrp gene mutation in mice, corresponding to a gene mutation in cartilage-hair hypoplasia patients, altered lncRNA chromatin occupancy, and reduced the DDX5-RORγt interaction and RORγt target gene transcription | 26675721 | ||||
| Interaction | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Interaction target | Level of interaction | Type of interaction | Description | PMID | Source | ||||
| DDX5 | RNA-Protein | binding | The ability of DDX5 to interact with RORγt and coactivate its targets depends on intrinsic RNA helicase activity and binding of a conserved nuclear long noncoding RNA (lncRNA), Rmrp, which is mutated in patients with cartilage-hair hypoplasia. | 26675721 | |||||