LncRNA Information
ID EL1097 Name PTENP1 Aliases PTEN-rs; PTEN2; PTENpg1; PTH2; psiPTEN
Species Homo sapiens Chromosome 9 Start site 33673504
End site 33677499 Chain minus Exon NO. 1
Assembly Ensembl Release 89 Class processed transcript NCBI accession NR_023917
Ensembl ENSG00000237984 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
tumor N/A N/A N/A regulation An example of this mechanism is represented by the tumour suppressor gene PTEN and its pseudogene PTENP1. 23660942 LncRNADisease
prostate cancer N/A N/A N/A regulation Oncogene; tumour suppressor 24373479 LncRNADisease
cancer N/A N/A N/A regulation PTENP1 pseudogene belongs to the group of competing endogenous RNAs (ceRNAs). It may act as “decoy” by protecting PTEN mRNA from binding to common miRNA and therefore allowing expression of the tumor suppressor protein.? 24757675 LncRNADisease
gastric cancer qPCR etc. cancerous gastric tissue, blood (serum) up-regulated expression A three-lncRNA signature, including CUDR, LSINCT-5 and PTENP1, was identified that may be potential diagnostic marker for GC. Moreover, a risk model for the serum three-lncRNA signature demonstrated that healthy samples can be distinguished from early GC samples. Three-lncRNA signature in serum was identified as diagnostic marker for GC. 25694351 Lnc2Cancer
hepatocelluar carcinoma qPCR, Western blot etc. HCC cell lines down-regulated expression Here we confirmed that PTENP1 and PTEN were downregulated in several HCC cells.These data colletcively unveiled the molecular mechanisms of how PTENP1 repressed the tumorigenic properties of HCC cells and demonstrated the potential of the SB-BV hybrid vetcor for PTENP1 lncRNA modulation and HCC therapy.PTENP1 repressed the tumorigenic properties of HCC cells and demonstrated the potential of the SB-BV hybrid vector for PTENP1 lncRNA modulation and HCC therapy. 25617127 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
PTEN RNA-RNA co-expression We find that PTENP1 is biologically active as it can regulate cellular levels of PTEN and exert a growth-suppressive role. 20577206 LncRNADisease