LncRNA Information
ID EL1056 Name PCAT6 Aliases KDM5B-AS1; KDM5BAS1; PCAN-R1; ncRNA-a2; onco-lncRNA-96
Species Homo sapiens Chromosome 1 Start site 202810954
End site 202812156 Chain plus Exon NO. 2
Assembly Ensembl Release 89 Class antisense NCBI accession NR_046325, NR_046326
Ensembl ENSG00000228288 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
triple-negative breast cancer microarray, qPCR etc. triple-negative breast cancer tissue up-regulated expression We found that the expression levels of TCONS_l2_00003938, ENST00000460164, ENST00000425295, MALAT1 and HOTAIR were significantly higher in tumor tissues than non-tumor tissues, whereas there were no significant differences in the expression levels of the other 3 lncRNAs. Our study identified a set of lncRNAs that were consistently aberrantly expressed in TNBC, and these dysregulated lncRNAs may be involved in the development and/or progression of TNBC. 25996380 Lnc2Cancer
prostate cancer microarray, RNA-seq, qPCR, Northern bolt, knockdown etc. prostate cancer tissue, cell lines (LNCaP, CWR22Rv1, PC3 etc.) up-regulated N/A Both lncRNA showed positive correlation between gene expression and SCNA. The criteria of increasing expression from normal to primary to metastatic prostate cancer aimed to uncover lncRNA that may be important therapeutic targets for both primary and metastatic cancers. 23728290 Lnc2Cancer
 


Interaction
Interaction target Level of interaction Type of interaction Description PMID Source
KLHL12 RNA-RNA co-expression When ncRNA-a2 was depleted, the KLHL12, a gene known for its negative regulation of the Wnt-beta catenin pathway, on the opposite strand displayed a significant reduction. 20887892 LncRNADisease
KLHL12 RNA-RNA regulation KLHL12, ROCK2, TAL1, CMPK1, Snai2, and Snai1 are regulated by ncRNA-a2 through ncRNA-a7, respectively. 21502407 LncRNADisease