LncRNA Information
ID EL1054 Name PCAT29 Aliases N/A
Species Homo sapiens Chromosome 15 Start site 69592129
End site 69695750 Chain plus Exon NO. 7
Assembly Ensembl Release 89 Class lincRNA NCBI accession NR_126437, NR_126438
Ensembl ENSG00000259641 Sequence


Disease
Disease Method Sample Expression pattern Dysfunction type Description PMID Source
prostate cancer microarray, qPCR etc. cell lines (Glutamax(Invitrogen), LNCaP, DU145 etc.) down-regulated N/A PCAT29 is suppressed by DHT and upregulated upon castration therapy in a prostate cancer xenograft model. PCAT29 knockdown significantly increased proliferation and migration of prostate cancer cells, whereas PCAT29 overexpression conferred the opposite effect and suppressed growth and metastases of prostate tumors in chick chorioallantoic membrane assays. Finally, in prostate cancer patient specimens, low PCAT29 expression correlated with poor prognostic outcomes. PCAT29 as an androgen-regulated tumor suppressor in prostate cancer. 25030374 Lnc2Cancer
prostate cancer qPCR, Western blot etc. cell lines (VCap, PC3M-luc, LNCaP etc.) down-regulated N/A This study reveals a novel tumor suppressive locus encoding two hormone-regulated lncRNAs, DRAIC and PCAT30, that are prognostic for a wide variety of cancer types.This study reveals a novel tumor suppressive locus encoding two hormone-regulated lncRNAs, DRAICand PCAT29, that are prognostic for a wide variety of cancer types. 25700553 LncRNADisease Lnc2Cancer