INTERACTION
ID	lncRNA Name	Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
EL1368	TSIX	TGF-β	RNA-Protein	regulation	The upregulation of TSIX seen in SSc fibroblasts may result from activated endogenous TGF-β signalling and may play a role in the constitutive upregulation of collagen in these cells.	26566700
EL1368	TSIX	collagen	RNA-RNA	regulation	TSIX is a new regulator of collagen expression which stabilizes the collagen mRNA.	26566700
EL1369	Tsix	XIST	RNA-DNA	regulation	Tsix directly regulates its transcription.	16507360	LncRNADisease
EL1369	Tsix	41186	RNA-Protein	binding	Oct4 directly binds Tsix and Xite, two regulatory noncoding RNA genes of the X-inactivation centre, and also complexes with XCI trans-factors, Ctcf and Yy1.	19536159	LncRNADisease
EL1369	Tsix	XIST	RNA-RNA	regulation	For the active X, the antisense Tsix RNA is an established Xist repressor.	21029862	LncRNADisease
EL1369	Tsix	XIST	RNA-DNA	regulation	Tsix represses Xist induction by several means, including altering the chromatin state of Xist, deploying Dnmt3a’s DNA methyltransferase activity, recruiting the RNAi machinery, and interfering with the ability of Xist and RepA RNA to engage Polycomb proteins.	21029862	LncRNADisease
EL1369	Tsix	XIST	RNA-RNA	regulation	Xist is controlled by two parallel RNA switches – Tsix for Xa and Jpx for Xi. Tsix represses Xist on Xa.	21029862	LncRNADisease
EL1369	Tsix	XIST	RNA-DNA	regulation	Epigenetically silences Xist expression by inhibiting RepA recruitment of polycomb complexes to maintain the active X chromosome in females.	21256239	LncRNADisease
EL1369	Tsix	RepA	RNA-RNA	regulation	Epigenetically silences Xist expression by inhibiting RepA recruitment of polycomb complexes to maintain the active X chromosome in females.	21256239	LncRNADisease
EL1369	Tsix	XIST	RNA-DNA	regulation	Tsix is associated with both enrichment of the H3K4me3 active mark and prevention of the deposition of the repressive mark H3K27me3 within the body of the Xist gene. Tsix, for instance, may be subject to Xist silencing at the onset of XCI.	21329697	LncRNADisease
EL1369	Tsix	XIST	RNA-RNA	regulation	The noncoding Tsix RNA is an antisense repressor of Xist and regulates X inactivation in mice.	21852535	LncRNADisease
EL1369	Tsix	Xist RNA	RNA-RNA	regulation	Tsix is instead required to silence Xist on the active-X as epiblast cells differentiate in both males and females.	25981039