INTERACTION
ID	lncRNA Name	Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
EL1399	TUG1	IgG	RNA-Protein	binding	binding with IgG shown by RIP-Chip data.	19571010	LncRNADisease
EL1399	TUG1	PRC2	RNA-Protein	binding	binding with PRC2 shown by RIP-Chip data.	19571010	LncRNADisease
EL1399	TUG1	p53	DNA-TF	regulation	TUG1 is induced by p53, binds to PRC2, and has a role in repressing specific genes involved in cell-cycle regulation.	19571010	LncRNADisease
EL1399	TUG1	PRC2	RNA-Protein	binding	TUG1 is induced by p53, binds to PRC2, and has a role in repressing specific genes involved in cell-cycle regulation.	19571010	LncRNADisease
EL1399	TUG1	PRC2	RNA-Protein	binding	Required for the proper formation of photoreceptors in the developing retina. Tug1 associates with PRC2 and represses a number of cell cycle genes.	21256239	LncRNADisease
EL1399	TUG1	Pc2	DNA-Protein	regulation	methylation/demethylation of Polycomb 2 protein (Pc2) controls relocation of growth-control genes between Polycomb bodies (PcGs) and interchromatin granules (ICGs) in response to growth signals. This movement is the consequence of binding of methylated and unmethylated Pc2 to the ncRNAs TUG1 and MALAT1/NEAT2.	22078878	LncRNADisease
EL1399	TUG1	polycomb repressive complex 2 (PRC2)	RNA-Protein	binding	binding to polycomb repressive complex 2 (PRC2),	25366138
EL1399	TUG1	miR-145	RNA-RNA	regulation	TUG1 decreased the expression of miR-145 and there was a reciprocal repression between TUG1 and miR-145 in an Argonaute2-dependent manner.	26318860
EL1399	TUG1	PRC2	RNA-Protein	binding	TUG1 could epigeneticly repress Kruppel-like factor 2 (KLF2) transcription in HCC cells by binding with PRC2 and recruiting it to KLF2 promoter region.	26336870
EL1399	TUG1	Kruppel-like factor 2 (KLF2)	RNA-Protein	regulation	TUG1 could epigeneticly repress Kruppel-like factor 2 (KLF2) transcription in HCC cells by binding with PRC2 and recruiting it to KLF2 promoter region.	26336870
EL1399	TUG1	Bcl-2	RNA-Protein	regulation	Taurine upregulated gene 1 promoted cell apoptosis of glioma cells by activating caspase-3 and -9-mediated intrinsic pathways and inhibiting Bcl-2-mediated anti-apoptotic pathways, acting as a tumor suppressor in human glioma.	26748401
EL1399	TUG1	caspase-3 and -9	RNA-Protein	regulation	Taurine upregulated gene 1 promoted cell apoptosis of glioma cells by activating caspase-3 and -9-mediated intrinsic pathways and inhibiting Bcl-2-mediated anti-apoptotic pathways, acting as a tumor suppressor in human glioma.	26748401
EL1399	TUG1	PTEN	RNA-DNA	regulation	The tumour-suppressive function of two lncRNAs (TUG1 and CTB-89H12.4) and their regulation of PTEN expression in prostate cancer.	26975529
EL1400	Tug1	PRC2	RNA-Protein	binding	Numerous lincRNAs are physically associated with PRC2.	19571010	LncRNADisease