INTERACTION
ID	lncRNA Name	Interaction target	Level of interaction	Type of interaction	Description	PMID	Source
EL0526	GAS5	NR3C1	RNA-Protein	binding	Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor. Gas5 bound to the DNA-binding domain of the glucocorticoid receptor (GR) by acting as a decoy glucocorticoid response element (GRE), thus competing with DNA GREs for binding to the GR.	20124551	LncRNADisease
EL0526	GAS5	NR3C1	RNA-Protein	regulation	The multifunctional GAS5 lncRNA is a negative regulator of the glucocorticoid receptor and other nuclear receptors.	20951849	LncRNADisease
EL0526	GAS5	miR-21	RNA-RNA	regulation	miR-21 is capable of suppressing the lncRNA growth arrest-specific 5 (GAS5). GAS5 can also repress miR-21 expression.	23933812
EL0526	GAS5	Annexin A2	RNA-Protein	binding	RNA pull-down experiment revealed a direct bind of lncRNA-GAS5 to a Ca2+-dependent RNA-binding protein, Annexin A2.	25806802
EL0526	GAS5	IGF-1R	RNA-DNA	regulation	GAS5 overexpression was inversely correlated with the expression of the EGFR pathway and IGF-1R proteins.	25925741
EL0526	GAS5	Y-box binding protein 1 (YBX1)	RNA-Protein	binding	lncRNA GAS5 was shown to interact with Y-box binding protein 1 (YBX1), and lncRNA GAS5 knockdown was shown to accelerate YBX1 protein turnover without affecting YBX1 transcription.	25959498
EL0526	GAS5	Plexin C1	RNA-Protein	regulation	The introduction of Gas5 by plasmid transfection increased the expression of tumor suppressor Bcl-2-modifying factor (bmf) and Plexin C1 via directly targeting and reducing the expression of miR-222.	26364613
EL0526	GAS5	tumor suppressor Bcl-2-modifying factor (bmf)	RNA-Protein	regulation	The introduction of Gas5 by plasmid transfection increased the expression of tumor suppressor Bcl-2-modifying factor (bmf) and Plexin C1 via directly targeting and reducing the expression of miR-222.	26364613
EL0526	GAS5	miR-21	RNA-RNA	regulation	Thus, GAS5 acts as a tumor suppressor in HCCs through negative regulation of miR-21 and its targets and proteins about migration and invasion in cancer cells.	26404135
EL0526	GAS5	miR-222	RNA-RNA	binding	A pulldown assay further validated that GAS5 could directly bind to miR-222.	26446789
EL0526	GAS5	BAX, BAK, cleaved-caspase 3 and cleaved-caspase 9	RNA-Protein	regulation	GAS5 could disrupt mitochondrial membrane potential and promote BAX, BAK, cleaved-caspase 3 and cleaved-caspase 9 expression.	26503132
EL0526	GAS5	miR-103	RNA-RNA	regulation	Through inhibiting the expression of miR-103, GAS5 significantly enhanced the expression of PTEN to promote cancer cell apoptosis.	26511107
EL0526	GAS5	Ki67	RNA-Protein	regulation	Lower GAS5 levels appeared in the patients with a high Ki67 proliferation index before surgery	26662314
EL0526	GAS5	vimentin	RNA-Protein	regulation	GAS5 negatively regulates vimentin expression in vitro and in vivo. Notably, vimentin knockdown promoted GAS5‑pcDNA3.1‑inhibition of hepatoma cell proliferation.	26707238
EL0526	GAS5	MMP2	RNA-Protein	regulation	Overexpressing lncRNA GAS5 inhibited the migration and invasion ability of melanoma SK-Mel‑110 cells, partially by decreasing the MMP2 expression and its activity.	26846479
EL0526	GAS5	phosphatase and tensin homologs (PTEN)	RNA-Protein	regulation	GAS5 suppresses cancer proliferation by acting as a molecular sponge for miR-21, leading to the de-repression of phosphatase and tensin homologs (PTEN), the endogenous target of miR-21.	27034004
EL0526	GAS5	miR-21	RNA-RNA	binding	GAS5 suppresses cancer proliferation by acting as a molecular sponge for miR-21, leading to the de-repression of phosphatase and tensin homologs (PTEN), the endogenous target of miR-21.	27034004